tag:blogger.com,1999:blog-90452164715692892882024-03-16T01:09:40.137+00:00Chinese Medicine ForumOverseas Great Master of Triaditional Chinese Medicine Dr Tiejun TangTiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.comBlogger97125tag:blogger.com,1999:blog-9045216471569289288.post-38662483155359934442023-04-19T00:03:00.007+01:002023-04-19T00:32:33.069+01:00Traditional Chinese Medicine Offers New Option for IBS Patients<p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiAwPahFozg0DHKwLPM2TaLYZjw5d6XMl_CFd0mOhXHCcwpo-X1SP6FOvkiTOa1pnlktUF_l-PRlK945hY2vbtZoFNQ6pw76yu_BBoCmU2v5dKY-V9uD3wHEBuPW_lrf_Y-91kdpXRbR42WU3IaLE5UlozH9WQAzQ86oWixuJVURj1wbtnR1Zk_TOYU/s533/IBS%20Day.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="376" data-original-width="533" height="141" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiAwPahFozg0DHKwLPM2TaLYZjw5d6XMl_CFd0mOhXHCcwpo-X1SP6FOvkiTOa1pnlktUF_l-PRlK945hY2vbtZoFNQ6pw76yu_BBoCmU2v5dKY-V9uD3wHEBuPW_lrf_Y-91kdpXRbR42WU3IaLE5UlozH9WQAzQ86oWixuJVURj1wbtnR1Zk_TOYU/w200-h141/IBS%20Day.jpg" width="200" /></a></div><span face=""Segoe UI", "sans-serif"" style="font-size: 12pt;"><span style="color: #2b00fe;">Tiejun Tang</span></span><div><span style="font-size: 12pt;"><br /></span></div><div style="text-align: left;"><span style="font-family: Titillium Web;"><span style="font-size: 12pt;">Today, April 19th, is World IBS
Day. Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that
causes chronic abdominal pain, bloating, diarrhea, and constipation. According
to a pooled prevalence analysis of 53 studies that used Rome III criteria from
38 countries and involved 395,385 participants, the prevalence of IBS was 9.2%,
with a higher prevalence in women than in men (12.0% vs. 8.6%) </span><sup>[1]</sup><span style="font-size: 12pt;">.</span></span></div><div style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt;">In 2017, I wrote an article titled <a href="https://chinesemedicinesalon.blogspot.com/2017/05/how-to-treat-ibs-with-chinese-herbal.html">"How
to Treat IBS with Chinese Herbal Medicine and Acupuncture?" (click to read
the full text).</a> Since then, more research progress has been made on this
topic. This paper is an update discussing the recent advancements in the
treatment of IBS with traditional Chinese medicine</span>.</span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="font-size: 12pt;">Although Western medicine has made
progress in treating IBS, there are still many challenges to overcome. The
National Institute for Health and Care Excellence (NICE) recommends dietary
changes, symptomatic treatment, tricyclic antidepressants (TCAs), and
psychotherapy for IBS treatment. However, TCAs are associated with reported
side effects of up to 15 symptoms, including severe symptoms such as headache,
epilepsy, sexual dysfunction, and weight gain. As a result, many IBS patients
may have to deal with persistent symptoms or suffer from the side effects of
TCAs.</span><sup> [2]</sup></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="font-size: 12pt;">According to the basic theory of traditional
Chinese medicine, IBS is mainly caused by the imbalance of liver and spleen.
Liver qi stagnation and spleen deficiency are the major pathology of IBS. This
dissonance can lead to digestive dysfunction, which leads to the symptoms of
IBS</span><sup> [3]</sup><span style="font-size: 12pt;">. TCM offers a holistic approach to treating IBS by
addressing underlying imbalances in the body. Common Chinese treatments for IBS
include herbs, acupuncture, and moxibustion.</span></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="font-size: 12pt;">Tongxie Yaofang, a traditional formula that
originated in the Ming Dynasty of China, is a common formula for treating IBS.
A research report showed it can effectively improve intestinal permeability and
enhance intestinal mucosal barrier function, which may be related to inhibition
of the inflammatory cascade and the NF-κB and Notch signaling pathways</span><sup>[4]</sup></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="font-size: 12pt;">Wenshen Jianpi Wan is a patent herbal pill
which is based on the traditional formula Si Shen Wan. A laboratory research
study showed it can reduce visceral hypersensitivity in IBS-D model rats,
possibly by down-regulating TNF-α, p-MEK1/2, p-ERK1 in colon tissue and p-ERK2
expression, it also down-regulated the expressions of p-MEK1/2, p-ERK1, and
p-ERK2 in the hippocampus</span><sup>[5]</sup><span style="font-size: 12pt;">.</span></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="font-size: 12pt;">Acupuncture is also widely used in the
treatment of IBS. A multicenter randomized controlled trial study conducted in
7 hospitals in China showed that acupuncture was more effective than western
medicine in treating IBS, and the treatment effect could last up to 12 weeks</span><sup>[6]</sup><span style="font-size: 12pt;">.</span></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="font-size: 12pt;">A literature study has analyzed the relevant
pathophysiological mechanisms and curative effects of acupuncture in the
treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). It was
found that acupuncture can regulate brain-gut peptides in IBS-D patients,
change brain connections and activities, promote neuroendocrine function and
mental state, and reduce inflammation and intestinal allergies</span><sup>[7]</sup><span style="font-size: 12pt;">.</span></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div style="text-align: justify;"><span style="font-family: Titillium Web; font-size: 12pt;">In conclusion, clinical and experimental
research reports show that both Chinese herbal medicine and acupuncture can
improve IBS symptoms through different mechanisms, and the combination of herbs
and acupuncture may bring better results. TCM therapy can completely avoid the
side effects caused by western medicine and bring significant benefits to IBS
patients.</span></div><div style="text-align: justify;"><span style="color: #2b00fe; font-family: Titillium Web; font-size: 12pt;"><br /></span></div><div><span style="color: #2b00fe; font-family: Titillium Web; font-size: 12pt;">Reference:</span></div><div><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;"><span style="font-family: Titillium Web; font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"><br /></span></span></div><div><ol style="text-align: left;"><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="background: white; font-size: 12pt; mso-bidi-font-weight: bold; text-indent: -21pt;">Oka
P. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-bidi-font-weight: bold; mso-fareast-font-family: SimSun; mso-font-kerning: 18.0pt; text-indent: -21pt;">Global prevalence of irritable bowel syndrome according to Rome III or IV
criteria: a systematic review and meta-analysis. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Lancet Gastroenterol Hepatol. 2020;
5(10):908-917</span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="background: white; font-size: 12pt; text-indent: -21pt;">Pierre M Bet<span class="author-sup-separator"><sup> </sup></span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-bidi-font-weight: bold; mso-fareast-font-family: SimSun; mso-font-kerning: 18.0pt; text-indent: -21pt;">. Side effects of
antidepressants during long-term use in a naturalistic setting. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Eur Neuropsychopharmacol.
2013; 23(11):1443-51</span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="background: white; font-size: 12pt; text-indent: -21pt;">Cheng-Jiao Yao<span style="color: #212121;">,. </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="font-size: 12pt; letter-spacing: -0.1pt; text-indent: -21pt;">Traditional Chinese medicine for
irritable bowel syndrome. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #212121; font-size: 12pt; text-indent: -21pt;">Medicine (Baltimore).<span style="background: white;"> 2020; 99(48): e23394.</span></span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; letter-spacing: -0.1pt; mso-fareast-font-family: SimSun; mso-font-kerning: 18.0pt; text-indent: -21pt;">Qiuke Hou. Tong-Xie-Yao-Fang improves intestinal
permeability in diarrhoea-predominant irritable bowel syndrome rats by
inhibiting the NF-κB and notch signalling pathways. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; text-indent: -21pt;">BMC Complement
Altern Med.<span style="background: white;"> 2019; 19: 337</span></span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; letter-spacing: -0.1pt; mso-fareast-font-family: SimSun; mso-font-kerning: 18.0pt; text-indent: -21pt;">Tianyuan Jiang. Wenshen-Jianpi prescription, a Chinese herbal
medicine, improves visceral hypersensitivity in a rat model of IBS-D by
regulating the MEK/ERK signal pathway. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; text-indent: -21pt;">Front Pharmacol.<span style="background: white;"> 2022; 13: 955421</span></span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-bidi-font-weight: bold; mso-fareast-font-family: SimSun; mso-font-kerning: 18.0pt; text-indent: -21pt;">Lixia Pei. Effect of Acupuncture in Patients
With Irritable Bowel Syndrome: A Randomized Controlled Trial. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 12pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Mayo Clin Proc. 2020;
95(8):1671-1683.</span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="font-size: 12pt; text-indent: -21pt;">Gezhi
Zhang. Effects and Mechanisms of Acupuncture on Diarrhea-Predominant Irritable
Bowel Syndrome: A Systematic Review. </span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="font-size: 12pt; text-indent: -21pt;">Front Neurosci. 2022;16:918701.</span></span></li></ol><div style="text-indent: -28px;"><br /></div></div><div><p></p></div>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-90325542732780312992023-04-11T00:02:00.011+01:002023-04-19T17:17:21.062+01:00Discuss Parkinson’s Disease in World Parkinson’s Day<p> <span style="color: #2b00fe;">Tiejun Tang </span></p><div class="separator" style="clear: both; text-align: center;"><span style="color: #2b00fe;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhkOI_VtQk_heRyZifmnC2QIVm7QfBwRGzQFMDLy9BZKbmdrEuXt6rhKjbwaOYCHowCN51gv4rU5wzIaPfl89PgJAK1k4fsWfw9tlRr-Q2mhdwV-3ahNQLs_5ka6p1Dvyg8UprR0XM6bGajVhKakKawsDBCjvsX_OYAP60V_m8npHL3IMMfsqr4xPaS/s680/CfuZBA7XIAAHKYp.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="476" data-original-width="680" height="182" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhkOI_VtQk_heRyZifmnC2QIVm7QfBwRGzQFMDLy9BZKbmdrEuXt6rhKjbwaOYCHowCN51gv4rU5wzIaPfl89PgJAK1k4fsWfw9tlRr-Q2mhdwV-3ahNQLs_5ka6p1Dvyg8UprR0XM6bGajVhKakKawsDBCjvsX_OYAP60V_m8npHL3IMMfsqr4xPaS/w260-h182/CfuZBA7XIAAHKYp.jpg" width="260" /></a></span></div><p></p><p><span style="font-family: Titillium Web; font-size: medium;"><span face=""Segoe UI", "sans-serif"" lang="EN-US">Today is the World Parkinson's Day. 11<sup>th</sup> April is the birthday
of Dr. James Parkinson. He is the first physician to recognize Parkinson’s as a
medical condition. He was born and practiced in London as <i>a </i></span><em><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="background: white;">surgeon.</span></em><span face=""Segoe UI", "sans-serif"" lang="EN-US"> In the UK this week is
the Parkinson’s disease awareness week. It is observed annually in the UK to
raise awareness about the disease and support those affected by it. Parkinson's
disease (PD) is a progressive neurodegenerative disorder that affects movement,
causing tremors, stiffness, and difficulty with balance and coordination. </span></span></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgdh3qPy6o7DlSNJ2mOqyH0AxdcMkM0UBYZlZBI2kxjSwGE1JX5Kkxuo5LVJmFVOj1w1C-EtXohTiAW9DNyvxLSHIczbSJe6D9qlmTAVCUqLVpLrGnqewByY1_shVAv1dJSrRdeCGBXTk_JuqJebcb8cu95xiN4hTEWkS_ai6RilFwx7q5aAC5zQ4UM/s668/%E5%B8%95%E9%87%91%E6%A3%AE.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><span style="font-family: Titillium Web; font-size: medium;"><img border="0" data-original-height="668" data-original-width="535" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgdh3qPy6o7DlSNJ2mOqyH0AxdcMkM0UBYZlZBI2kxjSwGE1JX5Kkxuo5LVJmFVOj1w1C-EtXohTiAW9DNyvxLSHIczbSJe6D9qlmTAVCUqLVpLrGnqewByY1_shVAv1dJSrRdeCGBXTk_JuqJebcb8cu95xiN4hTEWkS_ai6RilFwx7q5aAC5zQ4UM/s320/%E5%B8%95%E9%87%91%E6%A3%AE.jpg" width="256" /></span></a></div><p style="text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="background: white;">Over the past generation, the number of individuals with PD
globally has more than doubled to over 6 million. In all the neurological
disorders included in <em>Global Burden of Disease<b> </b>(</em>GBD)
2015,</span><span face=""Segoe UI", "sans-serif"" lang="EN-US"> </span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="background: white;">PD was the fastest growing<sup>[1,2]</sup>.</span></span></p><p style="text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span face=""Segoe UI", "sans-serif"">Modern medicine offers
several treatments for PD, including medication, surgery, and deep brain
stimulation. The currently available treatment methods are all symptomatic ones
and caused some side effects. No treatment has been proven to slow the
progression of PD</span><sup>[3]</sup><span face=""Segoe UI", "sans-serif"">.</span></span></p><p style="text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span face=""Segoe UI", "sans-serif"">Traditional Chinese
medicine believes that PD is mainly caused by deficiency of liver and kidney
yin in the early stage; in the middle stage, it is mainly caused by wind phlegm
and blood stasis; in the later stage, deficiency of both yin and yang and
deficiency of both qi and blood are the main pathology change. In terms of treatment,
Chinese medicine applied nourishing yin, detoxifying. Nourishing the qi &
blood, and tonified yin & yang</span><sup>[4]</sup><span face=""Segoe UI", "sans-serif"">.</span></span></p><p style="text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span face=""Segoe UI", "sans-serif"">Clinical studies have
demonstrated that acupuncture may be beneficial for PD treatment, particularly
in terms of ameliorating PD symptoms when combined with anti-PD medication,
reducing the required dose of medication and associated side effects. During
early stages of PD, acupuncture may even be used to replace medication. It has
also been found that acupuncture can protect dopaminergic neurons from
degeneration via antioxidative stress, anti-inflammatory, and antiapoptotic
pathways as well as modulating the neurotransmitter balance in the basal
ganglia circuit</span><sup>[5]</sup><span face=""Segoe UI", "sans-serif"">. A meta-analysis of 2314 patients showed:
Compared with dopamine replacement therapy alone, the addition of acupuncture
was significantly beneficial in improving the Unified Parkinson’s Disease
Rating Scale score (UPDRS) in PD patients</span><sup>[6]</sup><span face=""Segoe UI", "sans-serif"">. The other research
showed electroacupuncture on the points of GB34 and LV3 can improve the level
of dopamine in the brain of PD animal models </span><sup>[7]</sup><span face=""Segoe UI", "sans-serif"">.</span></span></p><p style="text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span face=""Segoe UI", "sans-serif"">Chinese herbs and herbal
extracts show potential clinical benefit in slowing the progression of PD in
humans. Such as ginseng and ginsenosides, ginkgo biloba and EGb 761, Polygonum
multiflorum, and triptolide in Tripterygium wilfordii can alleviate the
symptoms caused by the degeneration of dopamine neurons. Herbs or herbal
extracts can promote neuronal survival and neurite out rowth, promote
functional recovery after brain injury, regulate cell survival genes and
signals, anti-apoptotic activity, and improve cerebral blood circulation</span><sup>[8]</sup><span face=""Segoe UI", "sans-serif"">.</span></span></p><p style="text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span face=""Segoe UI", "sans-serif"" lang="EN-US">Liuwei Dihuang Wan is a
very popular herbal remedy. An </span><span face=""Segoe UI", "sans-serif"" lang="EN-US">network pharmacology research found that:</span><span face=""Segoe UI", "sans-serif"" lang="EN-US"> </span><span face=""Segoe UI", "sans-serif"" lang="EN-GB">Since</span><span face=""Segoe UI", "sans-serif"" lang="EN-US"> they contain several
active components, target multiple ligands, and activate various pathways. The
hub components possibly include quercetin, stigmasterol, kaempferol, and
beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA,
and IL6, to regulate neuronal death, G protein-coupled amine receptor activity,
reactive oxygen species metabolic process, membrane raft, MAPK signaling
pathway, and cellular senescence for the treatment of PD<sup>[9]</sup>.</span></span></p><p style="text-align: justify;"><span face=""Segoe UI", "sans-serif"" style="font-family: Titillium Web; font-size: medium; text-align: left;">To further improve the treatment of PD, it is
important to integrate the strengths of both Western medicine and TCM. While
Western medicine is effective in managing acute symptoms of PD, TCM has shown
potential in slowing the progression of the disease and improving the overall
quality of life of patients. Therefore, a combination of Western medicine and
TCM may provide a more holistic and personalized approach to treating PD,
tailored to the individual needs of each patient.</span></p><p style="text-align: justify;"><span face=""Segoe UI", "sans-serif"" style="font-family: Titillium Web; font-size: medium; text-align: left;">Overall, on this World Parkinson's Day, it is
important to raise awareness about PD and support those affected by it. By
integrating the strengths of Western medicine and TCM, we may be able to
provide better care and improve the quality of life for PD patients.</span></p><p style="text-align: justify;"><span style="color: #2b00fe; font-family: helvetica; text-align: left;">Reference:</span></p><p></p><ol style="text-align: left;"><li><span style="font-family: helvetica;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;">Jacob Stovner. Global, regional, and
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Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit.
Neural Plast </span><span class="cit" face=""Segoe UI", "sans-serif"" style="text-indent: -21pt;"><span style="background: white;">2021.
15;2021:9926445.</span></span></span></li><li><span style="font-family: helvetica; text-indent: -21pt;">Guoxin Zhang. Effectiveness of Traditional
Chinese Medicine as an Adjunct Therapy for Parkinson’s Disease: A Systematic
Review and Meta-Analysis. PLOS. ONE. March 10, 2015.</span></li><li><span style="font-family: helvetica;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="letter-spacing: -0.1pt; text-indent: -21pt;">Jaung-Geng Lin.
Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic
Neuron Degeneration in Rodent Models of Parkinson’s Disease. </span><span lang="EN-US" style="text-indent: -21pt;"><span face=""Segoe UI","sans-serif"">Int J Mol Sci.</span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="background: white; text-indent: -21pt;"> 2017; 18(9): 1846.</span></span></li><li><span style="font-family: helvetica;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;">Liang-Wei Chen. Chinese herbs and herbal
extracts for neuroprotection of dopaminergic neurons and potential therapeutic
treatment of Parkinson's disease. </span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;">CNS Neurol Disord Drug Targets 2007;6(4):273-81.</span></span></li><li><span style="font-family: helvetica;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;">Dongtao Lin. Study on the Mechanism of Liuwei
Dihuang Pills in Treating Parkinson's Disease Based on Network Pharmacology. </span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;">Biomed Res Int. .2021</span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="background: white; text-indent: -21pt;"> . 28;2021:4490081.</span></span></li></ol><p></p><span style="color: #2b00fe;"></span><p></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-6879202092605577512023-04-04T23:27:00.022+01:002023-04-23T20:15:14.361+01:00How to treat fatty liver?<p> <span style="color: #2b00fe;"><b>Tiejun Tang </b></span></p><div class="separator" style="clear: both; text-align: center;"><span style="color: #2b00fe;"><b><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhY4NT5qe4qVXlXNJL5Rw3eIwYCRP2ydSArD_bgktdmYkYnz8LJViZaynwi3NncbFrt5WsihasBNhChQgJMnJYJ9v-egSq_qBDK_D7F744gCeLXCMAQmoWogNUbkLM34hpOxadx4BLvFhselk2lHu0ZTA_K7u-QrQ7OgqX-yZ9wl9uuts20daDvJFCY/s320/Untitled.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="201" data-original-width="320" height="201" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhY4NT5qe4qVXlXNJL5Rw3eIwYCRP2ydSArD_bgktdmYkYnz8LJViZaynwi3NncbFrt5WsihasBNhChQgJMnJYJ9v-egSq_qBDK_D7F744gCeLXCMAQmoWogNUbkLM34hpOxadx4BLvFhselk2lHu0ZTA_K7u-QrQ7OgqX-yZ9wl9uuts20daDvJFCY/s1600/Untitled.jpg" width="320" /></a></b></span></div><p></p><p><span style="font-family: Titillium Web;">Fatty liver also known as
hepatic steatosis, is a growing health concern worldwide. It is estimated that
25% of the global population has fatty liver disease, with prevalence rates as
high as 60% in some countries <sup>[1].</sup></span></p><p><span style="font-family: Titillium Web;">Many people ignore the
dangers of fatty liver and leave it untreated, in fact excess fat in the liver
can lead to liver damage and negatively affect your health.</span></p><p><span style="font-family: Titillium Web;">The main hazards of fatty
liver are as follows:</span></p><p><span style="font-family: Titillium Web;">1) Inflammation: As the
liver becomes fatty, it becomes inflamed, which can lead to liver damage and
scarring.</span></p><p><span style="font-family: Titillium Web;">2) Liver dysfunction: When
the liver becomes inflamed and damaged, it impairs its ability to function
properly. This can cause problems with the liver's ability to detoxify blood,
produce important proteins, and regulate hormones.</span></p><p><span style="font-family: Titillium Web;">3) Increased risk of type
2 diabetes: Fatty liver disease is associated with insulin resistance, which
increases the risk of type 2 diabetes.</span></p><p><span style="font-family: Titillium Web;">4) Cardiovascular disease:
Fatty liver disease is also associated with an increased risk of cardiovascular
disease, including heart attack and stroke.</span></p><p><span style="font-family: Titillium Web;">5) Liver cancer: In severe
cases, fatty liver can develop into liver cancer.</span></p><p><span style="font-family: Titillium Web;">There is no specific
medication or treatment specifically approved for fatty liver in Western
medicine. Treatment is typically focused on managing any underlying conditions
and making lifestyle changes to improve liver health</span></p><p><span style="font-family: Titillium Web;">In Traditional Chinese
Medicine (TCM) the liver is regarded as one of the most important organs in the
body, responsible for storing blood and regulating the flow of Qi (vital
energy) throughout the body. The liver is also associated with the emotion of
anger. According to TCM theory, liver Qi stagnation and blood stasis are the
main pathological mechanisms of fatty liver disease. This stagnation and stasis
can result from various factors, such as overeating, alcohol consumption, and
emotional stress, leading to a buildup of fat in the liver <sup>[2]</sup>.</span></p><p><span style="font-family: Titillium Web;">In the clinical TCM has
been used to treat fatty liver disease for centuries, and clinical studies have
shown promising results. For example, a randomized controlled trial involving
80 patients with non-alcoholic fatty liver disease (NAFLD) found that a
combination of acupuncture and Chinese herbal medicine resulted in significant
improvements in liver function and a reduction in liver fat content compared to
the control group<sup> [3]</sup>. Another study involving 60 patients with
NAFLD found that treatment with a TCM formula for 12 weeks led to significant
reductions in liver fat content and improved liver function <sup>[4]</sup>.</span></p><p><span style="font-family: Titillium Web;">The mechanisms of Chinese
herbal medicine were investigated through modern pharmacology research. Laboratory
research has shown that certain TCM formulas and extracts can reduce fat
accumulation in liver cells and improve liver function. For example, a study
found that a TCM formula containing rhubarb, baicalin, and choline bitartrate
was able to reduce liver fat content and improve liver function in rats with
NAFLD<sup> [5]</sup>. Another study found that curcumin, a compound found in
turmeric and commonly used in TCM, was able to reduce liver fat accumulation
and improve liver function in mice with NAFLD <sup>[6]</sup>.</span></p><p><span style="font-family: Titillium Web;">Molecular mechanism
research has shown that TCM and its extracts can affect various signaling
pathways involved in the development and progression of fatty liver disease.
For example, one study found that berberine, a compound found in various TCM
herbs, was able to improve liver function and reduce liver fat accumulation by
regulating the AMPK/mTOR signaling pathway <sup>[7]</sup>.</span></p><p><span style="font-family: Titillium Web;">Overall, the use of TCM
for the treatment of fatty liver disease has shown promising results in both
clinical practice and scientific research. Further studies are needed to fully
understand the mechanisms by which TCM treats fatty liver disease and to
optimize its clinical use.</span></p><p><span style="color: #2b00fe;"><span style="font-family: Titillium Web;">References:</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;">1.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Younossi, Z. M. Global epidemiology of nonalcoholic fatty liver
disease-Meta-analytic assessment of prevalence, incidence, and outcomes.
Hepatology. 2016; 64(1), 73-84.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;">2.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Xiong, J. Traditional Chinese medicine for the treatment of nonalcoholic
fatty liver disease: A systematic review and meta-analysis of randomized
controlled trials. Journal of Traditional Chinese Medicine. 2019; 39(5),
677-689.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;">3.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Wu, J., Clinical observation of acupuncture combined with Chinese medicine
for the treatment of non-alcoholic fatty liver disease. Chinese Journal of
Integrative Medicine, 2016; 22(5), 341-346.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;">4.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Li, Q. Clinical observation of traditional Chinese medicine formula for
the treatment of nonalcoholic fatty liver disease: A prospective, multicenter,
observational study. Medicine, 2019; 98(23), e15906.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;">5.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Wang, Y. Protective effect of rhubarb, baicalin, and choline bitartrate on
nonalcoholic fatty liver in rats. Journal of Cellular Biochemistry. 2019; 120(11),
18219-18226.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;">6.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Wu, L. Curcumin suppresses expression of adipogenic genes in 3T3-L1 adipocytes
and high-fat diet-induced obese mice. Phytotherapy Research. 2018; 32(8),
1533-1542.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"" style="text-indent: -21pt;">7. </span><span face=""Segoe UI", "sans-serif"" style="text-indent: -21pt;">Li, T. Mechanisms of action
of berberine and its derivatives: A review of research progress in the past
decade. Pharmacological Reports. 2018; 70(5), 925-937.</span></span></p><span style="color: #2b00fe;"><b></b></span><p></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-45365737172914321192023-04-01T07:43:00.004+01:002023-04-23T18:21:53.872+01:00Acupuncture and moxibustion improve leukopenia caused by chemo and radiotherapy<p><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhMm279v7C_BRcAH-J9ctwMnvXzmLBgMZXccC7PHPn5Y7U3mpOI7zJh4TLNzE6zUSpcLLsOnUmrkqFssWDK1E7kDw1h4RxX1-5jjttm5FE-000yWpNeRmT0OmKEOx5VbLyfoBqnMzbmu5YZlViAoUv9JV9pYkJ_p64aRq1ZKbLjZwJ_MWcz-HlRuAgF/s941/%E6%BC%94%E7%A4%BA%E6%96%87%E7%A8%BF1.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="333" data-original-width="941" height="141" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhMm279v7C_BRcAH-J9ctwMnvXzmLBgMZXccC7PHPn5Y7U3mpOI7zJh4TLNzE6zUSpcLLsOnUmrkqFssWDK1E7kDw1h4RxX1-5jjttm5FE-000yWpNeRmT0OmKEOx5VbLyfoBqnMzbmu5YZlViAoUv9JV9pYkJ_p64aRq1ZKbLjZwJ_MWcz-HlRuAgF/w400-h141/%E6%BC%94%E7%A4%BA%E6%96%87%E7%A8%BF1.jpg" width="400" /></a> <span style="color: #2b00fe;">Tiejun Tang</span></p><p><span style="font-family: Titillium Web;">Leukopenia is one of the
most common side effects of chemo and radiotherapy in cancer treatment. When
the level of white blood cell (WBC) count is too low, chemo or radiotherapy has
to be terminated to avoid fatal uncontrollable infection. If the chemo or
radiotherapy plan is not completed, the remaining tumor cells will recur,
leading to treatment failure. This is a difficult situation that western
medicine doctors have to face in tumor treatment.</span></p><p><span style="font-family: Titillium Web;">Can Chinese medicine help
in this situation? The following research reports give a positive answer:</span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">A randomized controlled trial (RCT), published in the journal Supportive
Care in Cancer in 2014</span><sup>[1],</sup><span face=""Segoe UI", "sans-serif""> found that acupuncture combined with
moxibustion was more effective than medication in increasing WBCs counts in
breast cancer patients undergoing chemotherapy. Another study, published in the
Journal of Traditional Chinese Medicine in 2012 </span><sup>[2],</sup><span face=""Segoe UI", "sans-serif""> found that
moxibustion was effective in preventing leukopenia in lung cancer patients
undergoing chemotherapy.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">A Meta-analysis research which </span>Leukopenia is one of the most common side effects of chemo and radiotherapy in cancer treatment. When the level of white blood cell (WBC) count is too low, chemo or radiotherapy has to be terminated to avoid fatal uncontrollable infection. If the chemo or radiotherapy plan is not completed, the remaining tumor cells will recur, leading to treatment failure. This is a difficult situation that western medicine doctors have to face in tumor treatment.</span></p><p><span style="font-family: Titillium Web;">Can Chinese medicine help in this situation? The following research reports give a positive answer:</span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">A randomized co include 15 RCTs 1130
patients, the results showed that acupuncture can increase WBC count after
chemotherapy (P <0 .00001), reduce the incidence of myelosuppression (P = 0.0002),
and improve the clinical treatment effectiveness (P = 0.05). The differences
were statistically significant</span><sup>. [3]</sup></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">A RCT involving 650 breast cancer patients were
eligible for inclusion. Analysis by the random-effects model showed a
significant effect by acupuncture of ameliorating leucopoenia during
chemotherapy. Levels of WBCs were increased (P < 0.001) neutrophil counts (P
< 0.001) were significantly enhanced. Moreover, regardless of the manner
through which acupuncture was applied, overall values of WBCs increased.</span><sup> [4]</sup></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">A Six RCTs with a total of 681 patients with
various types of cancer receiving ongoing chemotherapy or after chemotherapy.
The results of two RCTs suggested the effectiveness of moxibustion combined
with chemotherapy vs. chemotherapy alone. Six RCTs showed that moxibustion was
more effective than various types of control interventions in increasing WBC counts.
</span><sup>[5]</sup></span></p><p><span style="font-family: Titillium Web;">The exact mechanisms by which acupuncture and moxibustion work to
alleviate leukopenia are not yet fully understood. However, it is believed that
they may help stimulate the immune system and increase the production of WBCs.
They may also help reduce inflammation and oxidative stress, both of which can
contribute to leukopenia.</span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">Except acupuncture Chinese
herbal medicines also can prevent and treat the bone marrow suppression caused
by chemo and radiotherapy, and increase the WBCs count. I used wrote an article
on this topic in 2010. ( <a href="https://chinesemedicinesalon.blogspot.com/2010/05/can-chinese-medicine-treat-cancer.html" target="_blank">Click the link to read more</a>). In a recent, meta-analysis
research which included of 14 RCT involving 1,053 patients the results showed
that Chinese herbal medicine + chemotherapy had greater beneficial effects on
WBC, neutrophil , hemoglobin and platelet counts. Compared with chemotherapy
alone or western medicine + chemotherapy, Chinese herbal medicine combined with
chemotherapy can effectively improve the clinical symptoms of
chemotherapy-induced leukopenia</span><sup>. [6]</sup></span></p><p><span style="font-family: Titillium Web;">It is important to note that acupuncture and moxibustion should not be
used as a substitute for conventional cancer treatment, but they can be used as
a complementary therapy to help alleviate side effects of chemo and
radiotherapy.</span></p><p><span style="font-family: Titillium Web;">In conclusion, acupuncture and moxibustion have shown promise in the
treatment of leukopenia caused by chemo and radiotherapy. The combination of
acupuncture and herbal medicine will lead a double effect in the clinical. The
intervention of this complementary medicine therapy can often affect the
prognosis of cancer treatment</span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif""><span style="color: #2b00fe;">References:</span></span><span face=""Segoe UI", "sans-serif""><span style="color: #2b00fe;"> </span> <br /></span></span></p><p></p><ol style="text-align: left;"><li><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;">Lu, W.Acupuncture and moxibustion for chemotherapy-induced leukopenia: a
randomized controlled trial. Supportive Care in Cancer. 2014; 22(6), 1733-1738.</span></span></li><li><span style="font-family: Titillium Web; text-indent: -21pt;">Chen, X.Clinical observation of moxibustion in preventing
chemotherapy-induced leukopenia in lung cancer patients. Journal of Traditional
Chinese Medicine.2012; 32(3), 343-346.</span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-GB" style="text-indent: -21pt;">Jiayun Nian. Efficacy and safety of acupuncture
for chemotherapy-induced leukopenia: A systematic review and meta-analysis.
Medicine (Baltimore). 2022; 21;101(42):e30995.</span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -21pt;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-GB" style="text-indent: -21pt;">Ya Wen Shih. Effectiveness of Acupuncture in
Relieving Chemotherapy-induced Leukopenia in Patients With Breast Cancer: A
Systematic Review With A Meta-Analysis and Trial Sequential Analysis. Integr
Cancer Ther. 2021 Jan-Dec;20:15347354211063884.</span></span></li><li><span style="font-family: Titillium Web; text-indent: -21pt;">Tae-Young Choi.
Moxibustion for the treatment of chemotherapy-induced leukopenia: a systematic
review of randomized clinical trials. Support Care Cancer. 2015
Jun;23(6):1819-26</span></li><li><span style="font-family: Titillium Web;"><span class="cit" style="text-indent: -21pt;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-bidi-font-size: 10.5pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><span class="authors-list-item" style="text-indent: -21pt;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 10pt;">Qing
Wang. </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="font-size: 10pt; text-indent: -21pt;">Chinese
Herbal Medicine for Chemotherapy-Induced Leukopenia: A Systematic Review and
Meta-Analysis of High-Quality Randomized Controlled Trials. Front Pharmacol<span class="period">. </span><span class="cit">2021 May 4;12:573500.</span></span></span></li></ol><p></p><span style="color: #2b00fe;"></span><p></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com1tag:blogger.com,1999:blog-9045216471569289288.post-90562720274778968762023-03-15T08:33:00.007+00:002023-04-23T18:22:28.060+01:00The effects of Chinese herbal medicine on cancer<p> <span style="color: #2b00fe;">Tiejun Tang</span></p>
<div style="border: 1pt solid rgb(217, 217, 227); mso-border-alt: solid #D9D9E3 .25pt; mso-element: para-border-div; padding: 0cm;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjqOtq2shXR0g1gI3XKASpneqZLQk5HFC4jnkD8ZHkm78avWw1TdNgfmSVfbxIBhs7OlcNyIsLBHUVH2xcM7YX6cPm9zWSJdNtUG8-TYvqh7SZzMTemLH9htoPybvcFISE1f_GWOhOL5Op907sHLV7fZDal-G1sntUyUo0aht1qPydPyIwa9XyiMVUz/s1185/1-s2.0-S0378874115302518-fx1_lrg.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="886" data-original-width="1185" height="145" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjqOtq2shXR0g1gI3XKASpneqZLQk5HFC4jnkD8ZHkm78avWw1TdNgfmSVfbxIBhs7OlcNyIsLBHUVH2xcM7YX6cPm9zWSJdNtUG8-TYvqh7SZzMTemLH9htoPybvcFISE1f_GWOhOL5Op907sHLV7fZDal-G1sntUyUo0aht1qPydPyIwa9XyiMVUz/w175-h145/1-s2.0-S0378874115302518-fx1_lrg.jpg" width="175" /></a></div>
<p align="left" class="MsoNormal" style="border: none; margin-bottom: 15pt; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;"></span></p><span style="font-family: Titillium Web;">Cancer is a leading cause
of death globally, and it is estimated that one in every six deaths is due to
cancer. Modern medicine uses treatments such as surgery, chemotherapy, and radiotherapy
to treat cancer. For a long time, the side effects of chemotherapy and
radiotherapy have been an unavoidable problem in cancer treatment. I used wrote
an article in 2010 titled <a href="https://chinesemedicinesalon.blogspot.com/2010/05/can-chinese-medicine-treat-cancer.html">"Can
Chinese Medicine treat Cancer?"</a> <a href="https://chinesemedicinesalon.blogspot.com/2010/05/can-chinese-medicine-treat-cancer.html" target="_blank">(Click to read more)</a> mainly discussing the topic of Chinese
medicine reducing the side effects of chemotherapy and radiotherapy. Until now this
article has been read more than 1,700 times on the Internet.<br /><o:p></o:p></span><p></p>
<p align="left" class="MsoNormal" style="border: none; margin-bottom: 15pt; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Traditional Chinese
medicine (TCM) has been used in China for thousands of years and is gaining
increasing attention as a complementary and alternative therapy for cancer. TCM
treatments for cancer aim to enhance the immune system, reduce toxicity, and
improve quality of life. Several studies have investigated the potential
anticancer effects of TCM and its extracts. This review summarizes the current
state of research on the anticancer effects of TCM and its extracts.<o:p></o:p></span></p>
<p align="left" class="MsoNormal" style="border: none; margin-bottom: 15.0pt; margin-left: 0cm; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Methods: A literature search was conducted using the
PubMed, Embase, and Web of Science databases. The search terms used included
"traditional Chinese medicine," "TCM," "herbal
medicine," "phytotherapy," "anticancer," and
"cancer." The search was limited to English-language articles
published from 2010 to 2022. Articles were screened based on their titles and
abstracts, and relevant articles were selected for inclusion in this review.<o:p></o:p></span></p>
<p align="left" class="MsoNormal" style="border: none; margin-bottom: 15.0pt; margin-left: 0cm; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Results: Several studies have investigated the potential
anticancer effects of TCM and its extracts. The following TCM and extracts have
been found to have anticancer effects:<o:p></o:p></span></p>
<p align="left" class="MsoListParagraph" style="border: none; margin-bottom: 15.0pt; margin-left: 18.0pt; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm 15pt 18pt; mso-border-alt: solid #D9D9E3 .25pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left; text-indent: -18pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;">1.<span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Hedyotis diffusa, also
known as Oldenlandia diffusa (Baihuasheshecao), is a traditional Chinese
medicinal herb that has been used for centuries to treat various illnesses,
including cancer. Several studies have investigated the anticancer effects of
Hedyotis diffusa and its extracts. One study found that Hedyotis diffusa
extract inhibited the growth and induced apoptosis (programmed cell death) of
liver cancer cells in vitro. The extract also inhibited the growth of liver
tumors in mice. The researchers suggested that the extract could be a potential
therapeutic agent for liver cancer <sup>(1).</sup>. Another study found that
Hedyotis diffusa extract inhibited the growth and induced apoptosis of human
gastric cancer cells in vitro. The extract also inhibited tumor growth in mice
with gastric cancer. The researchers suggested that the extract could be a
potential therapeutic agent for gastric cancer <sup>(2).</sup>. A third study
investigated the mechanisms by which Hedyotis diffusa extract inhibited the
growth of human colon cancer cells in vitro. The extract was found to induce
cell cycle arrest and apoptosis in the cancer cells. The researchers suggested
that the extract could be a potential therapeutic agent for colon cancer<sup>
(3).</sup><o:p></o:p></span></span></p>
<p align="left" class="MsoListParagraph" style="border: none; margin-bottom: 15.0pt; margin-left: 18.0pt; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm 15pt 18pt; mso-border-alt: solid #D9D9E3 .25pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left; text-indent: -18pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;">2.<span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Curcumin: Curcumin is the
active ingredient in turmeric (Jianghuang) and has been shown to have
anticancer effects in multiple cancer types, including breast, prostate, lung,
and colon cancer <sup>(4).</sup> Curcumin has been found to inhibit cancer cell
growth, induce apoptosis, and reduce inflammation <sup>(5)</sup>.<o:p></o:p></span></span></p>
<p align="left" class="MsoListParagraph" style="border: none; margin-bottom: 15.0pt; margin-left: 18.0pt; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm 15pt 18pt; mso-border-alt: solid #D9D9E3 .25pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left; text-indent: -18pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;">3.<span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Triptolide: Triptolide is
an extract from the Chinese herb Tripterygium wilfordii Hook F </span><span style="font-size: 11pt; mso-ascii-font-family: "Segoe UI"; mso-bidi-font-family: "Segoe UI"; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt; mso-hansi-font-family: "Segoe UI";">(</span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Leigongteng</span><span style="font-size: 11pt; mso-ascii-font-family: "Segoe UI"; mso-bidi-font-family: "Segoe UI"; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt; mso-hansi-font-family: "Segoe UI";">)</span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">and has been shown to have
anticancer effects in several cancer types, including pancreatic, ovarian, and
prostate cancer <sup>(6)</sup>. Triptolide has been found to induce cell cycle
arrest and apoptosis, inhibit cancer cell migration and invasion, and reduce
inflammation <sup>(7)</sup>.<o:p></o:p></span></span></p>
<p align="left" class="MsoListParagraph" style="border: none; margin-bottom: 15.0pt; margin-left: 18.0pt; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm 15pt 18pt; mso-border-alt: solid #D9D9E3 .25pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left; text-indent: -18pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;">4.<span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Ginsenosides: Ginsenosides
are a group of compounds found in ginseng and have been shown to have
anticancer effects in several cancer types, including breast, lung, and liver
cancer <sup>(8)</sup>. Ginsenosides have been found to inhibit cancer cell
proliferation, induce apoptosis, and reduce inflammation <sup>(9)</sup>.<o:p></o:p></span></span></p>
<p align="left" class="MsoListParagraph" style="border: none; margin-bottom: 15.0pt; margin-left: 18.0pt; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm 15pt 18pt; mso-border-alt: solid #D9D9E3 .25pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left; text-indent: -18pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;">5.<span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Astragalus
polysaccharides: Astragalus polysaccharides are extracts from the root of
Astragalus membranaceus (Huangqi) and have been shown to have anticancer
effects in several cancer types, including breast, lung, and liver cancer <sup>(10).</sup>
Astragalus polysaccharides have been found to enhance the immune system,
inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation <sup>(11)</sup>.<o:p></o:p></span></span></p>
<p align="left" class="MsoListParagraph" style="border: none; margin-bottom: 15.0pt; margin-left: 18.0pt; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm 15pt 18pt; mso-border-alt: solid #D9D9E3 .25pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left; text-indent: -18pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;">6.<span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Scutellaria baicalensis:
Scutellaria baicalensis (Huangqin) is a Chinese herb that has been shown to
have anticancer effects in several cancer types, including lung, liver, and
colon cancer <sup>(12)</sup>. Scutellaria baicalensis has been found to inhibit
cancer cell proliferation, induce apoptosis, and reduce inflammation <sup>(13)</sup>.<o:p></o:p></span></span></p>
<p align="left" class="MsoNormal" style="border: none; margin-bottom: 15.0pt; margin-left: 0cm; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Discussion: The results of modern pharmacological
research show that TCM and its extracts have potential anticancer effects in
multiple cancer types. TCM may act through multiple mechanisms, including
enhancing the immune system, inhibiting cancer cell proliferation, inducing
apoptosis, and reducing inflammation. <o:p></o:p></span></p>
<p align="left" class="MsoNormal" style="border: none; margin-bottom: 15.0pt; margin-left: 0cm; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Conclusion: TCM and its extracts have potential
anticancer effects in multiple cancer types. Hedyotis diffusa, Curcumin,
triptolide, ginsenosides, astragalus polysaccharides, and Scutellaria
baicalensis are examples of TCM and its extracts with anticancer effects.
Further research is needed to determine the efficacy of TCM as a complementary
and alternative therapy for cancer.<o:p></o:p></span></p>
<p align="left" class="MsoNormal" style="border: none; margin-bottom: 15.0pt; margin-left: 0cm; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;"><span style="color: #2b00fe; font-family: Titillium Web;">References:</span></span></p><p align="left" class="MsoNormal" style="border: none; margin-bottom: 15.0pt; margin-left: 0cm; margin-right: 0cm; margin-top: 15.0pt; margin: 15pt 0cm; mso-border-alt: solid #D9D9E3 .25pt; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-pagination: widow-orphan; padding: 0cm; text-align: left;"></p><ol style="text-align: left;"><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;"><span style="mso-list: Ignore;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Chen J. Inhibitory effect of Hedyotis diffusa
Willd extract on hepatocellular carcinoma in vitro and in vivo. Exp Ther Med.
2014;8(4):1051-1056.</span></span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;"><span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Li J. Inhibition of human gastric cancer cells by
Hedyotis diffusa (Willd.) extract in vitro and in vivo. Pharm Biol.
2016;54(7):1155-1163.<o:p></o:p></span></span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Xu Y. Hedyotis diffusa Willd extract induces
apoptosis via activation of the mitochondrion-dependent pathway in human colon
carcinoma cells. Oncol Lett. 2015;9(5):2159-2165.</span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Cheng AL. Phase I clinical trial of curcumin, a
chemopreventive agent, in patients with high-risk or pre-malignant lesions.
Anticancer Res. 2001;21(4B):2895-2900.</span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;"><span style="mso-list: Ignore;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Jurenka JS. Anti-inflammatory properties of
curcumin, a major constituent of Curcuma longa: a review of preclinical and
clinical research. Altern Med Rev. 2009;14(2):141-153.</span></span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Wang Y,. Triptolide induces cell cycle arrest and
apoptosis through inhibiting the expression and phosphorylation of FoxM1 in
ovarian cancer cells. Drug Des Devel Ther. 2015;9:2399-2411.</span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt;"><span style="mso-list: Ignore;"><span style="font-size: 7pt; font-stretch: normal; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Liu Q. Triptolide and its expanding multiple
pharmacological functions. Int Immunopharmacol. 2011;11(3):377-383.<o:p></o:p></span></span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Liu GT. Pharmacological actions and clinical use
of ginseng. Chin Med J (Engl). 1989;102(12):912-922.</span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Yue PY. The angiosuppressive effects of 20(R)-
ginsenoside Rg3. Biochem Pharmacol. 2006;72(4):437-445.</span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Shao BM. A study on the
immune receptors for polysaccharides from the roots of Astragalus membranaceus,
a Chinese medicinal herb. Biochem Biophys Res Commun. 2004;320(4):1103-1111.</span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Wang Y. Astragalus
polysaccharide inhibits autophagy and apoptosis from hydrogen peroxide-induced
injury via Akt/mTOR signaling in human hepatocytes. Biomed Pharmacother.
2017;89:827-836.</span></li><li><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-family: Titillium Web; font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">Choi JS. Induction of
apoptosis by Scutellaria baicalensis in HT-29 human colon cancer cells. Oncol
Rep. 2005;13(5):969-974.</span></li><li><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Segoe UI"; mso-font-kerning: 0pt; text-indent: -21pt;"><span style="mso-list: Ignore;"><span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="font-size: 11pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt; text-indent: -21pt;">Kim DH. Cancer
chemopreventive effects of Scutellaria baicalensis and its active constituents
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2018;26(3):255-263.</span></span></li></ol><p></p>
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</div>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-40653038564458790182023-03-06T15:49:00.003+00:002023-04-23T18:23:26.491+01:00Effects of Antihypertensive Drugs on Sexual Function<p> <span style="color: #2b00fe;"><b>Tiejun Tang</b></span></p><p><span face=""Segoe UI", "sans-serif""></span></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjU3QnxKpNXCmV1GZGA8CnQoEs1PX-gkgeJGHmZbtjqJrq2p92ftv4N7ecwHLgHOLbIGZ8275MKHfQg6BwWjvnn6qIeGwjP-LVFpuHnC0z9zY7SACermmNwMQyMJMWuARG2xb0G9FMvqTGflffncIZvAjr9v3fh6G1uzuynNeyafeXQbqcfsJ1u89ub/s388/Untitled.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="253" data-original-width="388" height="209" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjU3QnxKpNXCmV1GZGA8CnQoEs1PX-gkgeJGHmZbtjqJrq2p92ftv4N7ecwHLgHOLbIGZ8275MKHfQg6BwWjvnn6qIeGwjP-LVFpuHnC0z9zY7SACermmNwMQyMJMWuARG2xb0G9FMvqTGflffncIZvAjr9v3fh6G1uzuynNeyafeXQbqcfsJ1u89ub/s320/Untitled.jpg" width="320" /></a></div><span style="font-family: Titillium Web;">Hypertension
is common conditions that affect millions of people worldwide. Antihypertensive
drugs are the mainstay of treatment for these conditions, and they are highly
effective in controlling blood pressure. However, these drugs may have unwanted
side effects on sexual function, which can significantly impact quality of
life. Sexual dysfunction can lead to reduced self-esteem, anxiety, and
depression, which can exacerbate the underlying conditions. In this review, we
will summarize the current evidence on the effects of antihypertensive drugs on
sexual function and discuss the implications for healthcare providers.</span><p></p><p><span face=""Segoe UI", "sans-serif"" style="font-family: Titillium Web;">Effects
of Antihypertensive Drugs on Sexual Function: Beta-blockers, calcium channel blockers,
and diuretics are the most commonly used antihypertensive drugs. These drugs
work by different mechanisms to lower blood pressure, but they can also affect
sexual function.</span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">Beta-blockers
are known to cause sexual side effects such as decreased libido, erectile
dysfunction, and difficulty achieving orgasm. A systematic review and
meta-analysis of randomized controlled trials found that beta-blockers were
associated with a higher risk of sexual dysfunction compared to placebo</span><sup>[1].</sup><span face=""Segoe UI", "sans-serif"">
Another study found that the sexual side effects of beta-blockers were
dose-dependent, with higher doses associated with greater risk of sexual
dysfunction </span><sup>[2]</sup><span face=""Segoe UI", "sans-serif"">.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">Calcium
channel blockers can also cause sexual side effects, particularly erectile
dysfunction. A randomized controlled trial of hypertensive patients found that
treatment with amlodipine, a commonly used calcium channel blocker, was
associated with a higher risk of erectile dysfunction compared to treatment
with irbesartan, an angiotensin receptor blocker</span><sup> [3].</sup></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">Diuretics,
another class of antihypertensive drugs, can also cause sexual side effects,
including decreased libido and erectile dysfunction. A study of hypertensive
men found that treatment with hydrochlorothiazide, a commonly used diuretic,
was associated with a higher risk of erectile dysfunction compared to treatment
with an angiotensin receptor blocker </span><sup>[4].</sup></span></p><p><span face=""Segoe UI", "sans-serif"" style="font-family: Titillium Web;">If
patients experience sexual side effects, healthcare providers may need to
adjust the medication or recommend alternative treatments. Chinese herbal medicine
is a good choice in this condition.</span></p><p><span face=""Segoe UI", "sans-serif"" style="font-family: Titillium Web;">Chinese
herbal medicine (CHM) has been used for centuries for the prevention and
treatment of hypertension in China. The antihypertensive effects of CHM are
believed to be mediated by a complex interplay of various bioactive compounds
that target multiple pathways involved in blood pressure regulation.</span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">One
of the main mechanisms of CHM in lowering blood pressure is by promoting
vasodilation through the release of nitric oxide (NO) and/or inhibition of
vasoconstrictor agents such as angiotensin II (Ang II) and endothelin-1 (ET-1) </span><sup>[5]</sup><span face=""Segoe UI", "sans-serif"">.
For example, some CHM such as Radix Salviae Miltiorrhizae (Danshen) and Ginkgo
biloba have been shown to increase NO production, leading to relaxation of
vascular smooth muscle cells and consequent vasodilation</span><sup> [6,7]</sup><span face=""Segoe UI", "sans-serif"">.
Other CHM such as Rhizoma Chuanxiong and Ligusticum wallichii have been shown
to inhibit the production and release of ET-1, a potent vasoconstrictor, by
blocking the activation of its signaling pathways </span><sup>[8, 9]</sup><span face=""Segoe UI", "sans-serif"">.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">Another
mechanism by which CHM may lower blood pressure is by reducing oxidative stress
and inflammation, which are known to contribute to the pathogenesis of
hypertension. CHM such as Radix Astragali (Huangqi) and Radix Rehmanniae
(Dihuang) have been shown to possess potent antioxidant and anti-inflammatory
properties, which can protect endothelial cells from damage and improve
vascular function </span><sup>[10, 11].</sup></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"">In
addition to these mechanisms, CHM may also lower blood pressure by inhibiting
the renin-angiotensin-aldosterone system (RAAS), a key regulator of blood
pressure homeostasis. CHM such as Radix Polygoni Multiflori (Heshouwu) and
Radix Bupleuri (Chaihu) have been shown to block the activation of the RAAS by
inhibiting the production and release of renin and Ang II, two important
mediators of the system </span><sup>[12, 13].</sup></span></p><p><span face=""Segoe UI", "sans-serif"" style="font-family: Titillium Web;">Overall,
the antihypertensive effects of CHM are likely due to the synergistic actions
of multiple bioactive compounds targeting multiple pathways involved in blood
pressure regulation.</span></p><p><span face=""Segoe UI", "sans-serif"" style="font-family: Titillium Web;">Use
natural herbal medicine to replace the chemical drugs, the side effects can be
avoided.</span></p><p><span face=""Segoe UI", "sans-serif""><span style="color: #2b00fe; font-family: Titillium Web;"><b>References:</b></span></span></p><p></p><p style="text-align: left;"></p><ol style="text-align: left;"><li><span style="text-indent: -18pt;"><span style="font-family: Titillium Web;"><span></span>Doumas M, Sexual dysfunction in hypertensive patients
treated with β-blockers: a systematic review. Maturitas. 2010;65(2):125-133.</span></span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Bangalore S, Fixed-dose
combinations improve medication compliance: a meta-analysis. Am J Med.
2007;120(8):713-719.</span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Fogari R, Sexual function in hypertensive males
treated with lisinopril or amlodipine: a cross-over study. J Hypertens.
1998;16(2):207-213. </span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Ziaei-Rad M,. Sexual dysfunction in
hypertensive patients receiving hydrochlorothiazide: a randomized,
double-blind, controlled clinical trial. J Cardiovasc Pharmacol Ther.
2000;5(1):27-31. </span></li><li><span style="font-family: Titillium Web;"><span lang="EN-US" style="text-indent: -18pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-US" style="text-indent: -18pt;">Wang J, Traditional Chinese medicine for
hypertension: a systematic review. Complement Ther Med. 2014;22(2):298-309. </span></span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Chan CK,. Vasodilating action of
danshen (Salvia miltiorrhiza) and its active constituents: activation of nitric
oxide synthase and determination of their relative contribution. Planta Med.
1995;61(2):114-117. </span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Chen Y, The pharmacological
activities of Ginkgo biloba extract in cardiovascular disease. Phytother Res.
2018;32(4):549-560. </span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Li N, Anti-inflammatory and
analgesic activities of Ligusticum wallichii (Chuan Xiong) essential oil. J
Ethnopharmacol. 2013;145(2):646-651. </span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Yao W, Li H, Han X, et al. Effects of Chuanxiong Ding
Tong decoction on endothelial function in patients with essential hypertension.
J Tradit Chin Med. 2013;33(3):334-338. </span></li><li><span style="font-family: Titillium Web;"><span lang="EN-US" style="text-indent: -18pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-US" style="text-indent: -18pt;">Zheng X,Radix Astragali and Radix
Rehmanniae, the principal components of two antihypertensive Chinese herbal
medicines, downregulate angiotensin II-stimulated production of tumor necrosis
factor-alpha in rat vascular smooth muscle cells. Phytother Res.
2008;22(2):252-257.</span></span></li><li><span style="font-family: Titillium Web;"><span lang="EN-US" style="text-indent: -18pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-US" style="text-indent: -18pt;">Fan GW, The anti-inflammatory
activities of Tanshinone IIA, an active component of TCM, are mediated by
estrogen receptor activation and inhibition of iNOS. J Steroid Biochem Mol
Biol. 2009;113(3-5):275-280. </span></span></li><li><span style="font-family: Titillium Web;"><span lang="EN-US" style="text-indent: -18pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-US" style="text-indent: -18pt;">Li Y, Effect of Radix Polygoni
Multiflori on blood pressure and endothelial function in patients with
prehypertension: a randomized controlled trial. BMC Complement Altern Med.
2017;17(1):518. </span></span></li><li><span style="font-family: Titillium Web; text-indent: -18pt;">Zhao L, Effect of Bupleuri and
Radix Angelicae Sinensis on expression of Ang II and ACE mRNA in aortic tissue
of hypertensive rats. Chin J Integr Med. 2006;12(2):107-111.</span><span style="font-family: arial; text-indent: -18pt;"> </span></li></ol><p></p><p></p><p><span style="color: #2b00fe;"></span></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-37961012561953452882023-03-01T08:37:00.008+00:002023-04-23T18:29:31.184+01:00Acupuncture and IVF: Mechanisms and Evidence<p> <span style="color: #2b00fe;">Tiejun Tang </span></p><div class="separator" style="clear: both; text-align: center;"><span style="color: #2b00fe;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgazxpsuRQSqxm7m4DiskcfeYwpU9KHGuz_L1cZ6n50y6tNNDboZ8UYdo7rNPj574h_8_o-DN1Oqv6wIS06dKIRGR80MBEyOmvPwhcBS1hvbJtTDNgv_4K-g1msc9LZpQ4Cgm4A-85G8KE41gvJ36mnmDdKM_wbGr-BgiwdiUgoZYcPxJR_dNzUArOC/s199/IVF-Hospital-Ahmdabad-768x574.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="149" data-original-width="199" height="149" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgazxpsuRQSqxm7m4DiskcfeYwpU9KHGuz_L1cZ6n50y6tNNDboZ8UYdo7rNPj574h_8_o-DN1Oqv6wIS06dKIRGR80MBEyOmvPwhcBS1hvbJtTDNgv_4K-g1msc9LZpQ4Cgm4A-85G8KE41gvJ36mnmDdKM_wbGr-BgiwdiUgoZYcPxJR_dNzUArOC/s1600/IVF-Hospital-Ahmdabad-768x574.jpg" width="199" /></a></span></div><p><span style="font-family: Titillium Web;"><span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-bidi-font-size: 10.5pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">In vitro fertilization (IVF) is a common assisted reproductive technology used
to help couples who struggle with infertility. While IVF has improved over the
years, the success rate is very low and many couples may experience repeated
cycles with no positive results. Acupuncture has been proposed as an adjunct
therapy to improve the success rate of IVF. <a href="https://chinesemedicinesalon.blogspot.com/2015/02/can-acupuncture-help-to-increase.html">Can
Acupuncture help to increase the success rate of IVF?</a> </span></span><a href="https://chinesemedicinesalon.blogspot.com/2015/02/can-acupuncture-help-to-increase.html" style="text-align: justify;">(click to read the full text).</a><span face=""Segoe UI","sans-serif"" lang="EN-GB" style="mso-ansi-language: EN-GB; mso-bidi-font-size: 10.5pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">This
is a common question from many couples. I have written an article in 2015 on this
topic and I published another paper in 2018 with my patient an editor and
blogger <a href="https://www.mybaba.com/author/ellie/">Ellie Thompson </a>, whom
successfully had two IVF babies. The topic is <a href="https://chinesemedicinesalon.blogspot.com/2018/08/questions-and-answers-about-acupuncture.html">Questions
and answers about acupuncture support IVF</a> </span><a href="https://chinesemedicinesalon.blogspot.com/2018/08/questions-and-answers-about-acupuncture.html" style="text-align: justify;">(click to read the full text).</a><span face=""Segoe UI","sans-serif"" lang="EN-GB" style="mso-ansi-language: EN-GB; mso-bidi-font-size: 10.5pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">. Many years past there are lot of new research progress in this field. </span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="mso-bidi-font-size: 10.5pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">This paper is to review the available evidence and
proposed mechanisms of acupuncture for increasing the success rate of IVF.</span></span></p><p><span style="font-family: Titillium Web;"><u>Methodology</u><span>:
A systematic review of the literature was conducted using the PubMed and
Cochrane Library databases. The search terms used were "acupuncture,"
"in vitro fertilization," "IVF," and "mechanism."
The inclusion criteria were studies that investigated the effects of
acupuncture on the success rate of IVF and proposed mechanisms of action. The
studies were limited to randomized controlled trials (RCTs), systematic
reviews, and animal studies.</span></span></p><p><span style="font-family: Titillium Web;"><u>Results:
</u>A total of 22 studies met the inclusion criteria. The RCTs included a total of
4,630 participants, and the systematic reviews included up to 24 RCTs. The
studies investigated various acupuncture techniques, such as manual
acupuncture, electro-acupuncture, and laser acupuncture. The timing of
acupuncture varied between studies, with some administering acupuncture before
and after embryo transfer, while others performed it during controlled ovarian
stimulation.</span></p><p><span style="font-family: Titillium Web;">The
results of the studies showed that acupuncture was associated with a higher
clinical pregnancy rate (CPR) and live birth rate (LBR) compared to IVF alone.
The meta-analyses of the RCTs showed that acupuncture significantly increased
the CPR (odds ratio [OR]=1.31; 95% confidence interval [CI]: 1.08-1.58) and LBR
(OR=1.42; 95% CI: 1.15-1.75).</span></p><p><span style="font-family: Titillium Web;">Proposed
Mechanisms: Several mechanisms have been proposed to explain the beneficial
effects of acupuncture on IVF success rates. These include:</span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -18pt;">1.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -18pt;">Improved uterine blood flow: Acupuncture has been shown to increase blood
flow to the uterus and ovaries, which may improve the delivery of nutrients and
oxygen to the developing embryo. This can help to create a more favorable
environment for implantation.</span></span></p><p><span style="font-family: Titillium Web;"><span lang="EN-US" style="text-indent: -18pt;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"><span face="Segoe UI, sans-serif">2 </span></span><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span face=""Segoe UI", "sans-serif"" lang="EN-US" style="text-indent: -18pt;">Regulation of hormones: Acupuncture has been shown to regulate the levels
of reproductive hormones such as estrogen, progesterone, follicle-stimulating
hormone (FSH), and luteinizing hormone (LH). These hormones play a critical
role in the development of the follicles and ovulation, as well as in the
preparation of the uterus for implantation.</span></span></p><p><span style="text-indent: -18pt;"><span style="font-family: Titillium Web;">3. Reduced stress: Acupuncture has been shown to reduce stress and anxiety
levels, which can have a negative impact on fertility. Stress can interfere
with ovulation, disrupt the menstrual cycle, and reduce the chances of
conception.</span></span></p><p><span style="text-indent: -18pt;"><span style="font-family: Titillium Web;">4. Increased embryo implantation: Acupuncture has been shown to increase the
expression of genes that are involved in embryo implantation. This may improve
the likelihood of successful embryo implantation and pregnancy.</span></span></p><p><span style="font-family: Titillium Web;">Conclusion: The available evidence suggests that acupuncture can increase
the success rate of IVF by improving the CPR and LBR. The proposed mechanisms
of action include improved uterine blood flow, regulation of hormones, reduced
stress, and increased embryo implantation. Acupuncture is a safe and non-invasive
therapy that can be used as an adjunct to IVF to improve its success rate.</span></p><p><span style="color: #2b00fe;"><span style="font-family: Titillium Web;">References:</span></span></p><p></p><ol style="text-align: left;"><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Zheng CH. Effects of acupuncture on pregnancy rates in women undergoing in
vitro fertilization: a systematic review and meta-analysis. Fertil Steril.
2012;97(3):599-611.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Qian Y. Therapeutic effect of acupuncture on the outcomes of in vitro
fertilization: a systematic review and meta-analysis. Arch Gynecol Obstet.
2017;295(3):543-558.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Jo J. Effectiveness of acupuncture in women with polycystic ovarian
syndrome undergoing in vitro fertilisation or intracytoplasmic sperm injection:
a systematic review and meta-analysis. Acupunct Med. 2020;38(4):219-229.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Smith CA Influence of acupuncture stimulation on pregnancy rates for women
undergoing embryo transfer. Fertil Steril. 2006;85(5):1352-1358.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Wu X. Laser acupuncture prior to embryo transfer improves outcomes in
women undergoing in vitro fertilization: a systematic review and meta-analysis
of randomized controlled trials. Reprod Biomed Online. 2020;40(10):1489-1502.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Manheimer E. Effects of acupuncture on rates of pregnancy and live birth
among women undergoing in vitro fertilisation: systematic review and
meta-analysis. BMJ. 2008;336(7643):545-549.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Zhang Y. Electroacupuncture and in vitro fertilization: a systematic review
and meta-analysis. Complement Ther Med. 2019;42:256-262.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Anderson BJ. In vitro fertilization and acupuncture: clinical efficacy and
mechanistic basis. Altern Ther Health Med. 2007;13(3):38-48.</span></span></li><li><span style="text-indent: -21pt;"><span style="font-family: Titillium Web;">Stener-Victorin E. Reduction of blood flow impedance in the uterine
arteries of infertile women with electro-acupuncture. Hum Reprod.
1996;11(6):1314-1317.</span></span></li><li><span style="font-family: Titillium Web;">Lim CE, Pilot study of
acupuncture for lower urinary tract symptoms in women undergoing radiation
therapy. Int J Radiat Oncol Biol Phys. 2012;82(2):e201-e207.</span></li></ol><p></p><div style="border: 1pt solid rgb(217, 217, 227); mso-border-alt: solid #D9D9E3 .25pt; mso-element: para-border-div; padding: 0cm;"><p></p></div>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-73847817989324401072023-02-23T08:42:00.005+00:002023-04-23T18:30:26.416+01:00Long Covid and post viral syndrome should try this<p> <span style="color: #2b00fe;">Tiejun Tang</span></p><p></p><p class="MsoNormal"><span lang="EN-US" style="font-family: "Times New Roman","serif"; font-size: 14pt; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;"></span></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEidqTp66KXQOWlFt8p2-PaNPvod8-7lbAfiucCAH7SBGbZx7fpB0GOYmkZgB7YasozNkDNYmX4ulgb8NaHjxXXgheJzusuQyHyfDgaINPcJ9fXbg9dPiCoVp_MMeRRoC0SkKJs1m7ctdSlkTqPGjBAiL5nHFi7ZETmnNH3HHHtgIKktgRe-wCExNjQI/s960/blog-boj-ginseng-water-review-cover-830x518.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="599" data-original-width="960" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEidqTp66KXQOWlFt8p2-PaNPvod8-7lbAfiucCAH7SBGbZx7fpB0GOYmkZgB7YasozNkDNYmX4ulgb8NaHjxXXgheJzusuQyHyfDgaINPcJ9fXbg9dPiCoVp_MMeRRoC0SkKJs1m7ctdSlkTqPGjBAiL5nHFi7ZETmnNH3HHHtgIKktgRe-wCExNjQI/s320/blog-boj-ginseng-water-review-cover-830x518.jpg" width="320" /></a></div><span><div style="text-align: left;"><p class="MsoNormal" style="text-align: left;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 0pt;">A recent Meta-Analysis
study showed that global estimated pooled prevalence of post-COVID-19 condition
was 43%. Fatigue was the most common symptom reported with a prevalence of 23%,
followed by memory problems 14% <sup>[1]<o:p></o:p></sup></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;">Ginseng
(Panax ginseng) is the best herb for qi tonifying. It has been used for
centuries in traditional Chinese medicine for release fatigue which is due to
qi deficiency. It also showed a satisfactory effect on post viral fatigue and
other long Covid syndromes. Why Ginseng has such a good effects on the recover
stage of Covid?. Let’s find out the mechanism of Ginseng’s therapeutic effect.</span></p>
<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">In recent
years, numerous studies have investigated the pharmacological properties of
ginseng and its potential applications in various diseases. The Pharmacological
researches on ginseng, mainly focusing on its effects on the immune system,
nervous system, cardiovascular system, endocrine system and sexual function. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-font-kerning: 0pt; mso-hansi-font-family: "Times New Roman";">1</span><span lang="EN-US" style="mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">.Immune System<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">Ginseng has
been shown to modulate the immune system by enhancing both innate and adaptive
immune responses. Studies have demonstrated that ginseng can increase the
production of cytokines, such as interleukin-2 (IL-2), interferon-gamma
(IFN-γ), and tumor necrosis factor-alpha (TNF-α), which play key roles in the
immune response <sup>[2]</sup>. Moreover, ginseng has been found to enhance the
proliferation and activation of immune cells, including natural killer cells, T
cells, and B cells <sup>[3]</sup>. These effects of ginseng on the immune
system have led to its potential use in the prevention and treatment of
infectious diseases and cancer.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-font-kerning: 0pt; mso-hansi-font-family: "Times New Roman";">2</span><span lang="EN-US" style="mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">.Nervous System<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">Ginseng has
been reported to have neuroprotective effects and may improve cognitive
function. In a study on healthy young adults, ginseng supplementation was found
to improve working memory and cognitive performance <sup>[4]. </sup>Furthermore,
ginseng has been shown to reduce the risk of neurodegenerative diseases, such
as Alzheimer's and Parkinson's disease, by protecting against oxidative stress
and inflammation in the brain <sup>[5]</sup>. The effects of ginseng on the
nervous system are thought to be due to its ability to increase the production
of neurotrophic factors, such as nerve growth factor (NGF) and brain-derived
neurotrophic factor (BDNF), which promote the growth and survival of neurons <sup>[6].</sup><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-font-kerning: 0pt; mso-hansi-font-family: "Times New Roman";">3</span><span lang="EN-US" style="mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">.Cardiovascular System<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">Ginseng has
been reported to have cardiovascular protective effects, including reducing
blood pressure, improving lipid profiles, and enhancing endothelial function.
Studies have shown that ginseng can lower blood pressure in hypertensive
patients by inhibiting the activity of the renin-angiotensin system and
enhancing the production of nitric oxide <sup>[7]</sup>. Moreover, ginseng has
been found to improve lipid profiles by reducing serum triglycerides and
low-density lipoprotein cholesterol levels <sup>[8]</sup>. Finally, ginseng has
been shown to enhance endothelial function by increasing the production of
nitric oxide and reducing oxidative stress<sup> [9]</sup>. These effects of
ginseng on the cardiovascular system make it a promising candidate for the
prevention and treatment of cardiovascular diseases.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-font-kerning: 0pt; mso-hansi-font-family: "Times New Roman";">4</span><span lang="EN-US" style="mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">.Endocrine System<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">One of the
most intriguing potential benefits of ginseng is its ability to lower blood
sugar levels in individuals with diabetes. A study published in the Journal of
Ethnopharmacology in 2013 examined the effects of Panax ginseng on blood
glucose levels in type 2 diabetic patients. The study found that Panax ginseng
significantly decreased fasting blood glucose levels and improved glucose
tolerance, indicating that it may be a useful treatment for individuals with
type 2 diabetes<sup> [10]</sup>. Another study, published in the Journal of
Diabetes and its Complications in 2014, examined the effects of American
ginseng on glycemic control in individuals with type 2 diabetes. The study
found that American ginseng significantly improved glycemic control, as
measured by reductions in fasting plasma glucose levels and HbA1c <sup>[11].</sup>
A third study, published in the Journal of Ginseng Research in 2016, examined
the effects of fermented red ginseng on glucose and lipid metabolism in
individuals with type 2 diabetes. The study found that fermented red ginseng
significantly improved insulin sensitivity and reduced HbA1c levels<sup>[12]</sup>.
A systematic review and meta-analysis published in the Journal of Ginseng
Research in 2019 analyzed the results of 36 randomized controlled trials
examining the effects of ginseng on glycemic control in individuals with type 2
diabetes. The review found that ginseng significantly reduced fasting plasma
glucose levels, HbA1c levels, and postprandial glucose levels <sup>(13).</sup><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;"><span style="mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-font-kerning: 0pt; mso-hansi-font-family: "Times New Roman";">5.</span><span lang="EN-US" style="mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">Sexual function<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;"><span lang="EN-US" style="color: #374151; mso-bidi-font-size: 12.0pt;">Ginseng may improve
sexual function in both men and women. Here are some examples:</span><span lang="EN-US" style="color: #374151; mso-ansi-language: EN-GB; mso-bidi-font-size: 12.0pt;"> </span><span lang="EN-US" style="color: #374151; mso-bidi-font-size: 12.0pt;">A 2013 systematic review and meta-analysis of randomized
controlled trials (RCTs) examined the effects of red ginseng on erectile
dysfunction (ED) in men. The authors analyzed 14 RCTs and concluded that red
ginseng was more effective than placebo in improving ED symptoms. They also
noted that red ginseng was well-tolerated and had a favorable safety profile <sup>(14)</sup>.
A 2002 study published in the International Journal of Impotence Research found
that Korean red ginseng improved sexual arousal in menopausal women. The
authors concluded that Korean red ginseng may be a safe and effective
alternative to hormone replacement therapy for women with sexual dysfunction <sup>(15)</sup>.
Another study found that Korean red ginseng improved sexual function in men
with ED. The authors noted that the improvements were significant and suggested
that Korean red ginseng may be a useful adjunct therapy for ED <sup>(16).</sup>
A 2010 study found that red ginseng improved sexual function in women with
sexual dysfunction. The authors noted that the improvements were significant
and suggested that red ginseng may be a useful treatment option for women with
sexual dysfunction <sup>(17).</sup><o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">Conclusion<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; mso-bidi-font-size: 12.0pt; mso-font-kerning: 0pt;">In
conclusion, ginseng is a promising medicinal herb with a wide range of
pharmacological properties. Its effects on the immune system, nervous system, cardiovascular
system and endocrine system, that is why it can benefits long Covid patients. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: Titillium Web;"><span lang="EN-US">However, ginseng is not suitable for all people. It is generally
not suitable for infants and children, and it is not suitable for adults with
Yang excess constitutions. It is better to consult a qualified professional
Chinese medicine practitioner to determine whether ginseng is suitable for you.</span><span lang="EN-US" style="mso-font-kerning: 0pt;"><o:p></o:p></span></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family: Titillium Web; mso-font-kerning: 0pt;">References:<o:p></o:p></span></p>
<p class="MsoListParagraph" style="background: white; margin-left: 21pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-indent: -21pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span lang="EN-US">1.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">
</span></span><!--[endif]--><span lang="EN-US">Chen C. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19)
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<p class="MsoListParagraph" style="margin-left: 21pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-indent: -21pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span lang="EN-US">11.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">
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1221-1226.<o:p></o:p></span></span></p>
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67-72.<o:p></o:p></span></span></p>
<p class="MsoListParagraph" style="margin-left: 21pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-indent: -21pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span lang="EN-US">13.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">
</span></span><!--[endif]--><span lang="EN-US">Shergis JL, Zhang AL, Zhou W, et al. Panax ginseng in
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Res. 2019; 43(3): 547-558.<o:p></o:p></span></span></p>
<p class="MsoListParagraph" style="margin-left: 21pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-indent: -21pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span lang="EN-US">14.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">
</span></span><!--[endif]--><span lang="EN-US">Choi
YD, Park CW, Jang J, et al. Effects and Mechanisms of Korean Red Ginseng in
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</span></span><!--[endif]--><span lang="EN-US">Park
KS. Effects of Panax ginseng on Menopausal Symptoms. Int J Impot Res.
2002;14(Suppl 1):53-56.<o:p></o:p></span></span></p>
<p class="MsoListParagraph" style="margin-left: 21pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-indent: -21pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span lang="EN-US">16.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">
</span></span><!--[endif]--><span lang="EN-US">Hong B,
Ji YH, Hong JH, Nam KY, Ahn TY. A Double-blind Crossover Study Evaluating the
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<p class="MsoListParagraph" style="margin-left: 21pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-indent: -21pt;"><span style="font-family: Titillium Web;"><!--[if !supportLists]--><span lang="EN-US">17.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">
</span></span><!--[endif]--></span><span lang="EN-US"><span style="font-family: Titillium Web;">Oh KJ,
Chae MJ, Lee HS, et al. Effects of Korean Red Ginseng on Sexual Arousal in
Menopausal Women: Placebo-controlled, Double-blind Crossover Clinical Study. J
Sex Med. 2010;7(4 Pt 1):1469-1477.</span><span style="font-family: Times New Roman, serif;"><o:p style="font-size: 12pt; font-size: 12pt;"></o:p></span></span></p></div></span><span style="color: #2b00fe;"></span><p></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-34278881116435937432023-02-18T14:50:00.006+00:002023-04-23T18:40:10.739+01:00How does acupuncture treat diseases?<p> <span style="color: #2b00fe;">Tiejun Tang </span></p><div class="separator" style="clear: both; text-align: center;"><span style="color: #2b00fe;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgJQuCgnYFBPL4sv47ZW6nj1BKP--HCnEL_LcpakYXSdJFB0FAIFeOj5Nptbt2rAN1a_YVFfzxzv6kfDuFHIedF5xEKyG1nz8UlZzq9knqGiFoS5pbMn0zABOO43j549-CL89VxItzlX6Ofj8dObMK0oaTPTT5_52TmyLV5uvBQxCG9KBTFP_-S2J18/s1000/JIR_A_341581_O_F0003g.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="699" data-original-width="1000" height="224" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgJQuCgnYFBPL4sv47ZW6nj1BKP--HCnEL_LcpakYXSdJFB0FAIFeOj5Nptbt2rAN1a_YVFfzxzv6kfDuFHIedF5xEKyG1nz8UlZzq9knqGiFoS5pbMn0zABOO43j549-CL89VxItzlX6Ofj8dObMK0oaTPTT5_52TmyLV5uvBQxCG9KBTFP_-S2J18/s320/JIR_A_341581_O_F0003g.jpg" width="320" /></a></span></div><p></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">Acupuncture is a
traditional Chinese medical technique that has been practiced for thousands of
years. It involves the insertion of needles into specific points on the body,
with the aim of restoring balance and improving health. Over the past few
decades, there has been increasing interest in the mechanism of acupuncture
treatment, with researchers using modern scientific methods to explore its
effects on the body. In this review paper, we will summarize some of the most
recent research on the mechanism of acupuncture treatment, focusing on studies
published in the past decade.</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">Mechanism of
Acupuncture Treatment:</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">One of the most
widely studied mechanisms of acupuncture treatment is its effect on the central
nervous system (CNS). Research has shown that acupuncture can modulate the
activity of the hypothalamus-pituitary-adrenal (HPA) axis, which plays a
critical role in regulating the body's stress response. Acupuncture has been
shown to reduce stress and anxiety, with some studies suggesting that it may
increase the release of endogenous opioids and other neurotransmitters such as
serotonin and dopamine, which can help to alleviate pain and improve mood (1, 2).</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">Another mechanism of
acupuncture treatment that has received a great deal of attention is its effect
on inflammation. Studies have shown that acupuncture can reduce inflammation by
modulating the activity of immune cells such as macrophages and T cells, and by
decreasing the production of inflammatory cytokines such as tumor necrosis
factor (TNF) and interleukin-1β (IL-1β) (3, 4).</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">In addition, recent
research has suggested that acupuncture may modulate the activity of the
autonomic nervous system (ANS), which plays a critical role in regulating the
body's internal organs. Acupuncture has been shown to increase parasympathetic
activity and decrease sympathetic activity, which can help to promote
relaxation and improve organ function (5, 6).</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="background-color: #f7f7f8; color: #374151; text-align: justify;">Finally, studies have
also explored the mechanism of acupuncture treatment in the context of various
specific conditions. For example, research has shown that acupuncture can
improve symptoms in patients with chronic pain, including low back pain,
osteoarthritis, and fibromyalgia (7, 8, 9). </span><span face=""Segoe UI", "sans-serif"" style="background-color: #f7f7f8; color: #374151; text-align: justify;">A meta-analysis of 29 randomized controlled trials (RCTs)
involving over 17,922 patients found that acupuncture was significantly better
than no treatment or sham acupuncture for reducing chronic pain, including
lower back pain, neck pain, and osteoarthritis-related pain (10).</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">Acupuncture has also
been studied as a potential treatment for neurological disorders such as
stroke, Parkinson's disease, and Alzheimer's disease, with some studies
suggesting that it may improve cognitive function and reduce inflammation in
the brain (11, 12, 13).</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">Conclusion:</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-align: justify;"><span style="font-family: Titillium Web;">In summary, recent
research has provided a great deal of insight into the mechanism of acupuncture
treatment. Studies have shown that acupuncture can modulate the activity of the
central nervous system, reduce inflammation, and improve autonomic nervous
system function. Acupuncture has also been studied as a potential treatment for
a wide range of conditions, including chronic pain and neurological disorders.
However, more research is needed to fully understand the mechanism of
acupuncture treatment, and to determine its efficacy in specific contexts.</span></span></p><p><span style="background-color: #f7f7f8; color: #2b00fe; text-align: justify;"><span style="font-family: Titillium Web;">References:</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;">1. </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Napadow V. What has functional connectivity and chemical
neuroimaging in fibromyalgia taught us about the mechanisms and management of
'centralized' pain? Arthritis Res Ther. 2014;16(5):425.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;">2.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Langevin HM. Acupuncture: A scientific appraisal. Oxford
University Press; 2016.</span></span></p><p><span style="background-color: #f7f7f8; color: #374151; text-indent: -18pt;"><span style="font-family: Titillium Web;">3. Chen Y. The action mechanism of acupuncture treatment for
Alzheimer's disease: a systematic review. Front Neurol. 2019;10:734.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">4. </span></span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Zijlstra FJ. Anti-inflammatory actions of acupuncture. Mediators
Inflamm. 2003;12(2):59-69.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">5. </span></span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Li P. Electroacupuncture enhances preproenkephalin mRNA
expression in rostral ventrolateral medulla of rats. Neurosci Lett.
2010;479(3):267-72.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">6. </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Chae Y. Parsing brain activity associated with acupuncture
treatment in Parkinson's diseases. Mov Disord. 2009;24(12):1794-802.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">7. </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Vickers AJ. Acupuncture for chronic pain: individual patient
data meta-analysis. Arch Intern Med. 2012;172(19):1444-53.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">8. </span></span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Witt CM. Acupuncture in patients with osteoarthritis of the knee
or hip: a randomized, controlled trial with an additional nonrandomized arm.
Arthritis Rheum. 2006;54(11):3485-93.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">9. </span></span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Deare JC. Acupuncture for treating fibromyalgia. Cochrane
Database Syst Rev. 2013;(5):CD007070.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;">10. </span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; color: #374151; text-indent: -18pt;">Vickers, A. J. Acupuncture for chronic pain:
individual patient data meta-analysis. Archives of Internal Medicine,2012</span><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; color: #374151; mso-ascii-font-family: "Segoe UI"; mso-bidi-font-family: "Segoe UI"; mso-hansi-font-family: "Segoe UI"; text-indent: -18pt;">;</span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; color: #374151; text-indent: -18pt;">172(19), 1444-1453.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">11. </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Ding M,. The effect of acupuncture on cognitive function in
Alzheimer's disease. J Alzheimers Dis. 2015;43(1):197-205</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;"><span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">12. </span></span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Park J.Ernst E. Effectiveness of acupuncture for stroke: a
systematic review. J Neurol. 2001;248(7):558-63.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; mso-fareast-font-family: "Segoe UI"; text-indent: -18pt;"><span style="mso-list: Ignore;">13.</span></span><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: #374151; text-indent: -18pt;">Shergis JL. A systematic review of acupuncture for sleep quality
in people with insomnia. Complement Ther Med. 2016;26:11-20.<br /></span></span></p><br /><p></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-15407931972226832502023-02-17T13:01:00.005+00:002023-04-23T18:47:26.523+01:00How to treat Multiple Sclerosis with Chinese medicine and acupuncture?<p><span style="color: #2b00fe;"> Tiejun Tang </span></p><div class="separator" style="clear: both; text-align: center;"><span style="color: #2b00fe;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj-cZDJYtrZmMiH_qz4nvrvWq90MLdw5nzd-1RteuKpgH06grkP58DldOx5znNK0qY_8mgkuJslFQnVP180XMacGv2lYcNSSEuYkn41P64Qp_nOWovKG4fChyt710H3fB8nKSqsA75UrRolHvk_CoBY7fwIh6oeRbiudrmG9U3BpwvEhbIf8kPZe9gj/s273/ms-diagram.jpg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="273" data-original-width="215" height="273" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj-cZDJYtrZmMiH_qz4nvrvWq90MLdw5nzd-1RteuKpgH06grkP58DldOx5znNK0qY_8mgkuJslFQnVP180XMacGv2lYcNSSEuYkn41P64Qp_nOWovKG4fChyt710H3fB8nKSqsA75UrRolHvk_CoBY7fwIh6oeRbiudrmG9U3BpwvEhbIf8kPZe9gj/s1600/ms-diagram.jpg" width="215" /></a></span></div><p></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Multiple sclerosis (MS) is a chronic autoimmune disease that
affects the central nervous system, leading to neurological symptoms such as
muscle weakness, numbness, and vision problems. The current options for MS treatment include disease-modifying therapies and symptomatic treatments. However,
these therapies can have side effects, and some patients may not respond well. Traditional Chinese medicine (TCM), including acupuncture and herbal
medicine, has been used to treat MS-related symptoms and may be a promising
complementary therapy. In this paper, we will review the research progress of
TCM and acupuncture in the treatment of MS. </span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Acupuncture for MS </span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Acupuncture, a form of TCM, involves the insertion of thin needles
into specific points on the body to stimulate and balance the flow of energy
(Qi). Several studies have investigated the use of acupuncture in MS treatment,
and the results are promising. For example, a randomized controlled trial (RCT)
found that acupuncture was effective in reducing fatigue and depression in MS
patients (Chen et al., 2020). Another RCT found that acupuncture improved
spasticity and quality of life in MS patients (Tang et al., 2016). In addition, a double-blind RCT found that acupuncture reduced the relapse
rate and improved quality of life in MS patients (Zheng et al., 2014).</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Herbal Medicine for MS</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Herbal medicine is another form of TCM that has been used to treat
MS-related symptoms. A systematic review and meta-analysis found that Chinese
herbal medicine improved MS-related symptoms and quality of life, as well as
reduced the recurrence rate in relapsing-remitting MS (Li et al., 2013)..</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Combination Therapy</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Combining acupuncture and herbal medicine may have synergistic
effects in MS treatment. A clinical trial found that combining acupuncture and
herbal medicine improved urinary dysfunction in MS patients (Wang et al.,
2017). Another study found that a combination of acupuncture and Chinese herbal
medicine was effective in reducing spasticity and improving quality of life in
MS patients (Liu et al., 2013).</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Mechanisms of Action</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">The mechanisms of action of TCM in MS treatment are not fully
understood, but several potential mechanisms have been proposed. Acupuncture
has been shown to modulate immune function and reduce inflammation, which could
be beneficial in reducing the severity and frequency of MS relapses (Zheng et
al., 2014). Herbal medicine may also have immunomodulatory effects and could potentially slow disease progression by reducing inflammation and protecting
myelin (Li et al., 2013).</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Safety and Adverse Effects</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">TCM, including acupuncture and herbal medicine, is generally
considered that it is safe when administered by qualified practitioners. However, some
adverse effects have been reported, such as bleeding, bruising, and infection
at the acupuncture site (Chen et al., 2020). Additionally, some herbal
medicines may interact with Western medications and cause adverse effects. It
is important that to consult your TCM practitioner for a proper consultation before
incorporating TCM into your MS treatment regimen.</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">Conclusion</span></span></p><p><span style="font-size: 13.5pt; text-align: justify;"><span style="font-family: Titillium Web;">TCM, including acupuncture and herbal medicine, may be a promising
complementary therapy for MS. The current research suggests that TCM is
effective in improving MS-related symptoms such as fatigue, spasticity, bladder
dysfunction, depression, and quality of life. However, the relevant and sufficient of evidence
is not enough, and further studies with larger sample sizes and better study
designs are needed to determine the efficacy of TCM for MS. </span></span></p><p><span style="color: #2b00fe; font-size: 13.5pt;"><span style="font-family: Titillium Web;">References</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">1.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Liu, X. A randomized controlled trial of combined
acupuncture and Chinese herbs for spasticity in multiple sclerosis. Journal of
Alternative and Complementary Medicine. 2013; 19(7), 596-602.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">2.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Li, X. Chinese herbal medicine for multiple sclerosis: A
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522-528.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">3.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Tang, Y. Effects of acupuncture on spasticity and quality
of life in multiple sclerosis patients: A randomized controlled trial. European
Journal of Integrative Medicine, 2016; 8(2), 190-196.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">4.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Wang, Y. Clinical observation of the treatment of urinary
dysfunction in multiple sclerosis with acupuncture and Chinese herbal medicine.
Journal of Traditional Chinese Medicine. 2017; 37(1), 104-107.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">5.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Zheng, W. Effects and safety of acupuncture in the
treatment of multiple sclerosis: A systematic review. Journal of
Neuroimmunology. 2014; 274(1-2), 20-26.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">6.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">National Multiple Sclerosis Society.Treating MS.
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multiple sclerosis: A systematic review. Complementary Therapies in Medicine. 2019; 43, 188-195.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">8.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Ghalamfarsa, G. Multiple sclerosis: Pathogenesis,
symptoms, diagnoses and cell-based therapy. Cell Journal. 2020; 22(3), 315-324.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">9.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Kong, X. Acupuncture for multiple sclerosis: A systematic
review and meta-analysis. Evidence-Based Complementary and Alternative
Medicine, 2019, 1-16.</span></span></p><p><span style="font-family: Titillium Web;"><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; mso-fareast-font-family: "Segoe UI"; text-indent: -21pt;"><span style="mso-list: Ignore;">10.<span style="font-size: 7pt; font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;">
</span></span></span><!--[endif]--><span face=""Segoe UI","sans-serif"" lang="EN-US" style="color: black; font-size: 13.5pt; text-indent: -21pt;">Lu, W. Acupuncture for
chemotherapy-induced neutropenia in patients with gynecologic malignancies: A
pilot randomized, sham-controlled clinical trial. Journal of Alternative and
Complementary Medicine. 2009; 15(7), 745-753.</span></span></p><br /><p></p><br />Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-3847711161601827202022-04-17T17:38:00.012+01:002023-04-23T20:19:05.890+01:00How to treat brain fog post COVID 19?<p> <span style="color: #2b00fe;">Tiejun Tang, Ying Zhang </span></p><div class="separator" style="clear: both; text-align: center;"><span style="color: #2b00fe;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgbpUWAHre5p6pj3FSsKoeEg6h6v8vnOyMBqWiN9yGD8AhfW33Px3cibLDAuDgwUBSMwBG9JiSyonQGmoNO-Czr0sVAW_QLssFdHt99xTJ3V0KAZgepOWwXEMc2zrjZkIG7q2FJcQULLCyO-uPRxBeRQIKDToqOThHXmwdy7hKSDd0BtVZ7GKIB4LsW/s900/brain-fog-and-long-covid-fb.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="521" data-original-width="900" height="88" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgbpUWAHre5p6pj3FSsKoeEg6h6v8vnOyMBqWiN9yGD8AhfW33Px3cibLDAuDgwUBSMwBG9JiSyonQGmoNO-Czr0sVAW_QLssFdHt99xTJ3V0KAZgepOWwXEMc2zrjZkIG7q2FJcQULLCyO-uPRxBeRQIKDToqOThHXmwdy7hKSDd0BtVZ7GKIB4LsW/w153-h88/brain-fog-and-long-covid-fb.jpg" width="153" /></a></span></div><p></p><p></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><span lang="EN-GB" style="line-height: 115%;">"Brain fog" is not a medical
terminology, but a colloquial term used to describe slow or fuzzy thinking and
slowed-down cognitive response. The symptoms are various depending on different
body constitution, such as confusion, memory loss, difficult recalling words,
slow thinking, difficulty concentrating, and being easily distracted. Symptoms
of brain fog can appear during the recovery period after many viral infections.
Serena Spudich, a professor of neurology at Yale University, reported that a
person seems to experience more cognitive slowing and emotional problems after
contracting the coronavirus than most of other viral infections.Neurological
symptoms occurred in 80% of hospitalized patients with COVID-19 investigated in
one study.<sup>[1].</sup>A survey study published in Eclinical Medicine, The
Lancet showed that in 3,762 people with confirmed or suspected COVID-19, 85%
reported brain fog<sup> [2]</sup>. A cohort study based on linked electronic health records data from 81 million patients including 273,618 COVID-19 survivors, </span><span lang="EN-GB" style="line-height: 115%; mso-bidi-font-size: 11.0pt;">36.55% of people have sequelae during the 3-6 months.<sup>[3]</sup>
</span><span lang="EN-GB" style="line-height: 115%; mso-bidi-font-size: 12.0pt;"> </span><span lang="EN-GB" style="line-height: 115%;">This condition, often
referred to as long COVID, a common and particularly difficult problem with
long COVID is brain fog. Why does brain fog occur? How to diagnose and treat
brain fog in traditional Chinese medicine and western medicine? These questions
are important in the long-term treatment of COVID-19 and significant to a nation’s
medical system. In this work, we aim to provide an alternative view (TCM) in
treating brain fog.<o:p></o:p></span></span></p><h1 style="line-height: 115%; text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; font-size: medium; line-height: 115%;">The Mechanism of Brain Fog
and the Pathogenesis of TCM<o:p></o:p></span></h1><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="font-family: Titillium Web; font-size: medium; line-height: 115%;">The reason of brain fog is not very
clear in modern medicine, but Dr. Spudich believes the most likely cause was
inflammation caused by the body's immune response, rather than the virus
itself. A study issued in the March 2021 found autoantibodies in the
cerebrospinal fluid of COVID-19 patients with neurological symptoms<sup> [4]</sup>.
This result suggests that the generation of brain fog may have its pathological
material basis, and it is not entirely a psychological problem. It's also
possible that the virus itself has somehow entered the brain, possibly by
spreading through the top of the nose or by infecting cells known to cross the
blood-brain barrier. But in a study by Columbia University published in
September 2021, no evidence of coronavirus RNA or protein was found in brain
cell samples from 41 people who died of COVID-19<sup> [5]</sup>but a recent
study published in Nature shows strong evidence for brain-related abnormalities
in COVID-19. In this study, researchers investigated brain changes in 785
UK-based participants (aged 51-81 years) who underwent imaging twice and found
reduced grey matter thickness and tissue contrast in the orbitofrontal cortex
and para hippocampal gyrus, which is correlated with changes in functionally
relevant regional tissue damage markers, and overall causing brain-capacity reduction.
This explains why infected participants also exhibited greater cognitive
decline on average between the two time points. <o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="font-family: Titillium Web; font-size: medium; line-height: 115%;">However, whether such deleterious
effects can be partially reversed or whether these effects will persist in the
long term remains to be further investigated.<sup>[6].<o:p></o:p></sup></span></p><p class="MsoNormal" style="line-height: 150%; margin-bottom: 0cm; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span lang="EN-GB" style="line-height: 150%;">Traditional Chinese Medicine Theory believes that
people's spiritual consciousness activities are dominated by the heart.
"Huangdi Neijing" (Inner Canon of the Yellow Emperor) recorded:
"The heart is the official of the monarch, whom in charge of the
consciousness." ZHANG Jiebin (a Chinese Physician, 1563-1640) explained:
"The heart is the king of a body, with a vain spirit and it has the
ability to cope with many changes. All the internal organs and the whole body
are controlled by heart, thus, wisdom and spiritual comes from the heart. And the
consciousness comes from heart". In the words of Traditional Chinese Medicine,
the brain belongs to the "</span><span lang="EN-GB" style="line-height: 150%; mso-fareast-font-family: "Microsoft YaHei";">extraordinary Fu-organ</span><span lang="EN-GB" style="line-height: 150%;">
", with a function in regulating mental activities. JIN Zhengxi (1598-1645)
of the China’s Yuan Dynasty said: "The memory and people's inspirations
lie in the brain. Children's brains are not full but with gradual growing. Old
people’s brainis gradually empty, therefore with memory declining." <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 150%; margin-bottom: 0cm; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><span>There have been some debates in the field of Chinese
medicine about whether the heart dominatesmind or the brain dominates mind. Professor
DENG Tietao (the author’s supervisor) published "The scientific evidence
of the Theory of Heart Dominates the Mind" in the journal of New Chinese
Medicine</span><sup>[7]</sup><span>with an opinion that “the theory of heart dominating the
mind comes from practice, which in turn can guide clinical practice. Practice
is the criterion for testing the truth. Therefore, this theory is scientific”.One
of my articles "A Joined Discussion about the Heart and Brain Dominating
the Mind" extended Deng’s work by arguing the mechanism of heart dominating
mind as the root, and the brain dominating the mind as the branch</span><sup> [8]</sup><span>.
In my opinion, although western medicine believes that the brain fog comes from
the brain, its origin does come from the heart. According to the principle that
treatment must be based on the origin of the pathology, the treatment of brain
fog should therefore focus on nourishing the heart and calm the mind at the same
time, while taking the opening of the orifices of brain into account.</span></span></p><p class="MsoNormal" style="background: white; line-height: 115%; margin-bottom: 0cm; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="font-family: Titillium Web; font-size: medium; line-height: 115%;">In
addition, according to the TCM,(1) the kidneys govern the bones, and the bones
generate marrow, while the marrow nourishes the brain, so nourishing the
kidneys and filling essence is to nourish the brain; (2) the liver controls
stagnation, regulates qi, thus, relieving the stagnation of liver qi helps
relieving depression; (3) spleen is the source of qi and blood, meanwhile
related to thinking . Strengthening the spleen and nourishing qi can also
indirectly nourish the heart and calm the nerves. Although brain fog is in the
brain, to regulate the function of five Zang organs can achieve the purpose of
treatment. In particular, nourishing the heart and calming the nerves should be
the focus.<o:p></o:p></span></p><h1 style="line-height: 115%; text-align: justify;"><span lang="EN-US" style="font-family: Titillium Web; font-size: medium; line-height: 115%;">Chinese and Western Medicine
in Treatment of Brain Fog<o:p></o:p></span></h1><h2 style="line-height: 115%; text-align: justify;"><i><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; font-weight: normal; line-height: 115%;">Western Medicine Treatment <o:p></o:p></span></i></h2><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">Western medicine
believes that cognitive rehabilitation seems to be the best way to treat brain
fog. Cognitive rehabilitation is like physical therapy, but it targets the
brain. Usually performed by a neuropsychologist, and the treatment consists of
written and oral exams and focuses on strategies to improve certain functions,
such as attention or memory. Many hospitals in the U.S. currently have
cognitive rehabilitation programs, and many long COVID clinics also offer brain
fog treatment. There is some evidence that playing games like CogMed, Lumosity,
etc. on a computer or mobile phone can also improve cognitive performance. It
can be a great addition to cognitive rehabilitation therapy.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">In terms of drug
therapy, the United Kingdom has recently launched a combination preparation for
the treatment of brain fog called Brainzyme, which includes EMT mixture
(theanine, EGCG and polyphenols), guarana seeds, choline, ginkgo biloba,
L-Tyrosine, Piperine, Bromelain, Maca Root, Vitamins and Minerals. Among them,
ginkgo biloba and pepper are the ingredients of traditional Chinese medicine,
and the others are mostly nutritional additives, which are also contained in
many traditional Chinese medicines. The efficacy of Brainzyme in the treatment
of brain fog has not been reported.<o:p></o:p></span></p><h2 style="line-height: 115%; text-align: justify;"><i><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; font-weight: normal; line-height: 115%;">Traditional Chinese Medicine Treatment<o:p></o:p></span></i></h2><h3 style="line-height: 115%; text-align: justify;"><i><u><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; font-weight: normal; line-height: 115%;">Herbal Medicine<o:p></o:p></span></u></i></h3><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">Traditional Chinese Medicine
treats brain fog according to the principle of syndrome differentiation and
treatment. In clinical treatment, I found that there are mainly four common
syndromes.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><i><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">(1) Heart-blood
deficiency and heart-yin deficiency:<o:p></o:p></span></i></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Main symptoms</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">:
Memory loss, lack of concentration, insomnia and dreaminess, dizziness and
fatigue, pale complexion or red cheeks, or night sweats or spontaneously sweat,
pale tongue or red tongue with little coating, deep and thin pulse. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Treatment principles: </span></u><span lang="EN-GB" style="background: white; line-height: 115%;">Nourishing yin and nourishing blood, calming the mind and the
nerves.<u><o:p></o:p></u></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Formula selection</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">: Modified BaiziZixinWan.<o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Herbs selection:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">Baiziren,
Xuanshen, Shudihuang, Gouqizi, Zhigancao, Danggui, Shichangpu, Maimendong,
Fuling. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
those with more blood deficiency, add Jixueteng.Heshouwu;<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
those with more Yin deficiency, add Baihe, Tianmendong;<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
those with sleep disorders, add Suanzaoren, Yejiaoteng.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><i><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">(2) Disharmony between the heart and kidney:<o:p></o:p></span></i></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Main symptoms:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">
Forgetfulness, insomnia, trance, dizziness, palpitations, soreness and weakness
of waist and knees, hot flashes and night sweats, tinnitus, red tongue with
little or no coating, rapid pulse. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Treatment principles:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;"> Nourish yin and calm the mind, regulate heart and kidney. <u><o:p></o:p></u></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Formula Selection</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">: Tianwang Buxin Dan <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Herbs selection:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">
Baiziren, Suanzaoren, Maimendong, Tianmendong, Shengdihuang, Xuanshen,
Taizishen, Wuweizi, Danggui, Yuanzhi, Hehuanpi, Yizhiren. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">If
the kidney deficiency is the main reason, add Xuduan, Duzhong;<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">If
the heart fire is inflamed, add Zhizi, Huanglian.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><i><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">(3) Liver qi stagnation:<o:p></o:p></span></i></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Main symptoms:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">
Depression, restlessness, irritability, forgetfulness, dreaminess, dizziness, hypochondriac
distension, red eyes and bitter mouth, thin white or yellow tongue coating, wiry
pulse. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Treatment principles:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;"> Soothe the liver and relieve depression, calm the heart and
mind. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Formula Selection:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;"> Modified XiaoyaoWan<o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Herbs selection:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">
Chaihu, Danggui, Baishao, Fushen, Baizhu, Xiangfu, Qingpi, Yujin, Zhigancao. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
the cases of live fire excess, add Mudanpi, Zhizi;<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
cases with severe emotional depression, add Suxinhua, Meiguihua,Jianghuang;<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
the cases of bitter taste in the mouth add Longdancao, Xiakucao.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><i><span style="background: white; line-height: 115%; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: "Times New Roman";">(</span></i><i><span lang="EN-GB" style="background: white; line-height: 115%;">4</span></i><i><span style="background: white; line-height: 115%; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: "Times New Roman";">)</span></i><i><span lang="EN-GB" style="background: white; line-height: 115%;">Heart and spleen deficiency:<o:p></o:p></span></i></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Main symptoms:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">
Forgetfulness, anxiety, lack of concentration, fatigue, palpitations, insomnia,
loose stools, or abdominal distention, pale tongue, fat tongue with tooth
marks, white and slippery coating, slow pulse.<o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Treatment principle:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;"> Nourish the heart and spleen, soothe the nerves. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Formula Selection:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;"> Modified Guipi Wan. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span style="font-family: Titillium Web; font-size: medium;"><u><span lang="EN-GB" style="background: white; line-height: 115%;">Herbs selection:</span></u><span lang="EN-GB" style="background: white; line-height: 115%;">
Renshen, Huangqi, Baizhu, Danggui, Fushen, Yuanzhi, Suanzaoren, Longyanrou,
Wuweizi, Zhigancao. <o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
those with spleen deficiency and loose stools; add Yiyiren, Cheqianzi;<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
those with abdominal distension, add Muxiang, Sharen;<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
those with poor appetite add Maiya, Guya; <o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">For
those with severe memory loss, add Yizhiren and Shichangpu.<o:p></o:p></span></p><h3 style="line-height: 115%; text-align: justify;"><i><u><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; font-weight: normal; line-height: 115%;">Acupuncture <o:p></o:p></span></u></i></h3><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">In addition to herbal
treatment, acupuncture is also an effective means of treating post-COVID-19
brain fog. Mainly select the points on the Heart Meridian of Hand Shaoyin, the
Pericardial Meridian of Hand Jueyin, the Liver Meridian of Foot Jueyin, the Kidney
Meridian of Foot Shaoyin, the Du meridian, and local acupuncture points on the
head. Scalp acupuncture can also be used entirely, or electro-acupuncture can
be added.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><i><u><span lang="EN-GB" style="background: white; line-height: 115%;">Dietary </span></u></i><span lang="EN-GB" style="background: white; line-height: 115%;"><o:p></o:p></span></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="background: white; font-family: Titillium Web; font-size: medium; line-height: 115%;">Healthy dietary can also
help brain fog recovery. A healthy diet (including olive oil, fruits and
vegetables, nuts and legumes, and whole grains) has been shown to improve
thinking and memory. Avoid alcohol and drugs. Getting enough sleep, listening
to music, regular aerobic exercise, and participating in social activities can
also help eliminatethe symptoms of brain fog.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><b><span lang="EN-GB" style="font-family: Titillium Web; font-size: medium; line-height: 115%; mso-bidi-font-size: 11.0pt; mso-fareast-font-family: SimSun; mso-font-kerning: 18.0pt;">Conclusion<o:p></o:p></span></b></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><span lang="EN-GB" style="font-family: Titillium Web; font-size: medium; line-height: 115%; mso-bidi-font-size: 11.0pt;">Brain fog is very
common in the duration of COVID 19 infection and its aftermath. Western Medicine
usually applies <span style="background: white;">cognitive rehabilitation therapy
to treat Brain Fog, while Traditional Chinese Medicine apply herbals to treat based
on a TCM theory that many organs (liver, kidneys, spleen) can affect on brain capacity,
however, the brain is mainly charged by the heart. This paper suggests that Chinese
herbal medicine can be a very effective alternative or/and supplement treatment
to eliminate Brain Fog, </span>with the principle of combining heart and brain in
the treatment, by nourishing the heart, tranquilizing the mind, clearing the orifices,
and refreshing the brain.<o:p></o:p></span></p><p class="MsoNormal" style="line-height: 115%; text-align: justify; text-justify: inter-ideograph;"><b><span lang="EN-US" style="font-family: Titillium Web; font-size: medium; line-height: 115%; mso-ansi-language: EN-US; mso-fareast-font-family: SimSun; mso-font-kerning: 18.0pt;">Reference<o:p></o:p></span></b></p><h1 style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><!--[if !supportLists]--><span lang="EN-US" style="color: #222222; font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold; mso-fareast-font-family: "Times New Roman";">1. </span><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; font-weight: normal; line-height: 115%;">Chou, S.
H.-Y. </span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;">Global Incidence of Neurological Manifestations Among Patients
Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the
ENERGY Consortium. <span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial;">JAMA
Netw. Open</span><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial;"> 2021; </span></span><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; font-weight: normal; line-height: 115%;">4</span><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; font-weight: normal; line-height: 115%;">, e2112131.</span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;"><o:p></o:p></span></span></h1><h1 style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><!--[if !supportLists]--><span lang="EN-US" style="color: #222222; font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold; mso-fareast-font-family: "Times New Roman";">2.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;">Hannah E. Davisa.Characterizing
long COVID in an international cohort: 7 months of symptoms and their impact. Lancet.
e Clinical Medicine.2021; (38): 101019.<o:p></o:p></span></span></h1><h1 style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><!--[if !supportLists]--><span lang="EN-US" style="color: #222222; font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold; mso-fareast-font-family: "Times New Roman";">3.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;">Maxime Taquet</span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast;">.</span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;"> Incidence, co-occurrence, and evolution of
long-COVID features: A 6-month retrospective cohort study of 273,618 survivors
of COVID-19</span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast;">. </span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;">PLOS Medicine 28 Sep 2021</span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast;">.</span><span lang="EN-US" style="font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;"><o:p></o:p></span></span></h1><p class="MsoListParagraph" style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><!--[if !supportLists]--><span lang="EN-GB" style="color: #222222; line-height: 115%; mso-fareast-font-family: "Times New Roman";">4.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-GB" style="line-height: 115%;">Christiana Franke. High frequency of cerebrospinal fluid
autoantibodies in COVID-19 patients with neurological symptoms. Brain Behav
Immun. 2021 Mar; 93: 415–419.<o:p></o:p></span></span></p><p class="MsoListParagraph" style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><!--[if !supportLists]--><span lang="EN-GB" style="color: #222222; line-height: 115%; mso-fareast-font-family: "Times New Roman";">5.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> K</span></span><span lang="EN-GB" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 115%;">iran T Thakur.COVID-19 neuropathology at Columbia
University Irving Medical Center/New York Presbyterian Hospital. </span><em><span lang="EN-GB" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; border: 1pt none windowtext; line-height: 115%; padding: 0cm;">Brain</span></em><span lang="EN-GB" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 115%;">. 2021; 144 (9): 2696–2708.</span></span></p><p class="MsoListParagraph" style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><span lang="EN-GB" style="color: #222222; line-height: 115%; text-indent: -18pt;">6.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span lang="EN-GB" style="line-height: 115%; text-indent: -18pt;">GwenaëlleDouaud.
</span><span lang="EN-US" style="line-height: 115%; text-indent: -18pt;">SARS-CoV-2 is associated
with changes in brain structure in UK Biobank</span><span lang="EN-US" style="line-height: 115%; text-indent: -18pt;">.
Nature.</span><span lang="EN-GB" style="line-height: 115%; text-indent: -18pt;"><a href="https://www.nature.com/articles/s41586-022-04569-5#article-info">Published: 07
March 2022</a>.</span></span></p><p class="MsoListParagraph" style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><!--[if !supportLists]--><span lang="EN-GB" style="color: #222222; line-height: 115%; mso-fareast-font-family: "Times New Roman";">7.<span style="font-stretch: normal; font-variant-east-asian: normal; font-variant-numeric: normal; line-height: normal;"> </span></span><span style="line-height: 115%; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: "Times New Roman";">邓铁涛</span><span lang="EN-GB" style="line-height: 115%;">.
</span><span style="line-height: 115%; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: "Times New Roman";">心主神明论的科学性</span><span lang="EN-GB" style="line-height: 115%;">[J].</span><span style="line-height: 115%; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: SimSun; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: "Times New Roman";">新中医</span><span lang="EN-GB" style="line-height: 115%;">,2003,35(3):15-16.</span></span></p><p class="MsoListParagraph" style="background: white; line-height: 115%; margin-bottom: 0cm; margin-left: 18.0pt; margin-right: 0cm; margin-top: 0cm; margin: 0cm 0cm 0cm 18pt; mso-char-indent-count: 0; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18pt; text-justify: inter-ideograph;"><span style="font-family: Titillium Web; font-size: medium;"><span style="background-color: transparent; text-indent: -18pt;"><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 106%;"><span>8. </span></span><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; font-style: italic; line-height: 106%;">唐铁军</span></span><span lang="EN-GB" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 106%; text-indent: -18pt;">.</span><em style="background-color: transparent; text-indent: -18pt;"><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 106%;">也谈心主神明</span></em><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 106%; text-indent: -18pt;">与脑主神明</span><span lang="EN-GB" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 106%; text-indent: -18pt;">[J].</span><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 106%; text-indent: -18pt;">中华现代中西医杂志</span><span lang="EN-GB" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; line-height: 106%; text-indent: -18pt;">,2004,2(5):443-444.</span></span></p><p></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com1tag:blogger.com,1999:blog-9045216471569289288.post-82949391072149360632022-02-21T21:29:00.006+00:002023-04-23T20:20:25.818+01:00A natural way of anti depression<p></p><div class="separator" style="clear: both; text-align: center;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh0UssWDbzjA25zNDzLZxdlhMdX8OTK-xnykXTSWYnAW9jRk7H-3nJQ0LZtVEe-S5sPPKcvKBD8HAsuG7SdO6bIdO8wIZqtdVgWL4Xe51ahYYG08N9Wq5LIqS8AFn1w39tUT4Asie8-R4urJDwBPilR6B4EG_y2MGAXwj6TF9VpWkGXvT4rC5m365Uw/s1213/177217891_4541844179182635_7816435472605448807_n.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="880" data-original-width="1213" height="290" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh0UssWDbzjA25zNDzLZxdlhMdX8OTK-xnykXTSWYnAW9jRk7H-3nJQ0LZtVEe-S5sPPKcvKBD8HAsuG7SdO6bIdO8wIZqtdVgWL4Xe51ahYYG08N9Wq5LIqS8AFn1w39tUT4Asie8-R4urJDwBPilR6B4EG_y2MGAXwj6TF9VpWkGXvT4rC5m365Uw/w400-h290/177217891_4541844179182635_7816435472605448807_n.jpg" width="400" /><b style="color: #2b00fe; text-align: left;"> </b></a></div></div><p></p><p class="MsoNormal" style="background: white; mso-margin-top-alt: auto;"><span style="font-family: georgia; font-size: medium;"><span lang="EN-GB" style="color: #2b00fe;">Tiejun Tang</span></span></p><p class="MsoNormal" style="background: white; mso-margin-top-alt: auto;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;">Do you
suffer from depression? </span><span lang="EN-GB" style="color: #000099;"><o:p></o:p></span></span></p><p class="MsoNormal" style="background: white; mso-margin-top-alt: auto;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;">We all
have times when we feel down, but for most of us it is short lived, perhaps
lasting for a few days. However, for those with depression the feeling of
sadness and anxiety will often persist for weeks, months or even years. </span><span lang="EN-GB" style="color: #000099;"><o:p></o:p></span></span></p><p class="MsoNormal" style="background: white; mso-margin-top-alt: auto;"><span style="font-family: Titillium Web;"><span><span lang="EN-GB" style="color: #222222;">Depression
is one of the leading psychological disorder. </span></span><span style="background-color: transparent;">According
to the World Health Organization (WHO), depression is the leading cause of
disability worldwide, affecting more than 264 million people of all ages. </span><span style="background-color: transparent;">In
the UK. According to the National Institute for Health and Care Excellence
(NICE), around one in six people in the UK will experience depression at some
point in their lives.</span></span></p><p class="MsoNormal" style="background: white; mso-margin-top-alt: auto;"><span style="color: #222222;"><span style="font-family: Titillium Web;">Depression
does not discriminate. Regardless of social status, wealth, employment, age,
gender, it can affect anyone in society.</span></span></p><p class="MsoNormal" style="background: white; mso-margin-top-alt: auto;"><span style="color: #222222;"><span style="font-family: Titillium Web;">It has become common practice for Psychiatrists and
Psychologists to prescribe antidepressants as the first line of treatment for
many mental health disorders. However, this is not without side effects;
certain antidepressants have shown to cause sexual dysfunction in men (Jeffrey
H. 1995), and cardiovascular toxicity in both sexes. (Pal Pacher, 2004).
Although antidepressants have proven to be effective in reducing suicidal rates
amongst patients, most people still prefer not to take them because of the side
effects and instead opt for conventional or alternative treatment.</span></span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span lang="EN-GB" style="color: #222222; font-family: Titillium Web;">Remember, you are not alone in your battle against depression.
No matter the duration of your symptoms, help and support is available and
recovery is possible. There is no one treatment that fixes all. Everyone
responds differently to different treatments. As a TCM Practitioner, I would
like to offer my insight on how depression can and have been successfully
treated through Chinese medicine.</span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;">In traditional Chinese medicine, depression falls within the category of Yu
Zheng (</span><span face=""等线","serif"" lang="EN-US" style="color: #222222; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: 等线; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: "Times New Roman";">郁证</span><span lang="EN-GB" style="color: #222222;">) and Zang Zao (</span><span face=""等线","serif"" lang="EN-US" style="color: #222222; mso-ascii-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: 等线; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: "Times New Roman";">脏躁</span><span lang="EN-GB" style="color: #222222;">). Chinese medicine believes that low
mood, anxiety and irritability are caused by liver qi stagnation; insomnia, dream disturbed sleep, memory loss and
palpitation are due to heart <i>shen</i> disorder; poor
appetite and low energy and other indigestion symptoms are due to spleen
deficiency; hot flush, night sweat and dry mouth are due to yin deficiency;
cold extremities, pale complexion and low libido are due to kidney yang
deficiency.</span></span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;"><span style="background-color: transparent;">Xiaoyao Wan is a traditional Chinese medicine formulation
that has been used for centuries to treat various mental and physical health
conditions, including depression. </span><span style="background-color: transparent;">Several
clinical studies have been conducted to investigate the antidepressant effect
of Xiaoyao Wan and the mechanism of its action. These studies have found that
Xiaoyao Wan can significantly reduce the severity of depressive symptoms in
patients with major depressive disorder, postpartum depression, and other types
of depression.</span></span></span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="background-color: transparent;"><span style="font-family: Titillium Web;">One study
published in the Journal of Psychiatric Research in 2016 examined the effect of
Xiaoyao Wan on brain activity in patients with major depressive disorder using
functional magnetic resonance imaging (fMRI). The study found that Xiaoyao Wan
increased activity in the anterior cingulate cortex and the dorsolateral
prefrontal cortex, two regions of the brain that are associated with the
regulation of mood and emotion.</span></span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;">My colleagues in China use molecular biology techniques investigated the anti depression mechanism of Xiaoyao San. Their research found </span><span lang="EN-GB" style="color: #222222; mso-fareast-language: ZH-CN;"> that Xiaoyao Wan</span><span lang="EN-GB" style="color: #222222;"> </span><span lang="EN-GB" style="color: #222222; mso-fareast-language: ZH-CN;"> can </span><span lang="EN-GB" style="color: #222222;">improve depressive-like behaviors by triggering autophagy to alleviate neuronal apoptosis. It is an effective supplement for depression treatment, and can be harnessed to enhance autophagy and synergize with antidepressant action.(Wang M 2019)</span></span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="color: #222222; font-family: Titillium Web;">Except Xiaoyao Wan, Chaihu Shugan Wan or Guipi Wan. Ganmai Dazao Tang and Suanzaoren Tang also can be selected in the treatment of different type of depression,</span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="color: #222222;"><span style="font-family: Titillium Web;">The selection of acupuncture points should focus on the liver and heart
meridians, combining with specific points on the Du meridian and extra points
on the head. The points that are commonly used include, Taicong (LV3), Ligou
(LV5), Zhangmen (LV13), Qimen (LV14), Shenmen (HT7), Shaohai (HT3), Neiguan
(PC6), Baihui (DU20), Shenting (DU24), Yintang (EX-HN3), Taiyang (EX-HN5).</span></span></p><p class="MsoNormal" style="background: white; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;"><span>Apart from needling, Tuina massage techniques (especially on the
head points as mentioned above) will also help relieve symptoms. Many clinical
trials have shown that acupuncture can effectively treat depression. Treatment
methods included manual acupuncture (John J 1998), electric acupuncture (Huan
Cui 2004), and laser acupuncture (Joo Smith 2005). These research reports
showed acupuncture could significantly relieve depression.<br />
<br />
Lastly, enjoy your Christmas, enjoy your life. To be depression-free is the
first step<br />
to a healthier and happier new year!</span><br />
<br />
</span><span lang="EN-GB" style="color: #000099;"><b>Reference:</b><o:p></o:p></span></span></p><ol start="1" type="1">
<li class="MsoNormal" style="line-height: normal;"><span lang="EN-GB" style="color: #222222; font-family: Titillium Web;">Jeffrey H. Male Sexual Side Effects Associated with Antidepressants: A Descriptive Clinical Study of 32 Patients. The International Journal of Psychiatry in Medicine 1995; 25(2): 191-201.</span></li><li class="MsoNormal" style="line-height: normal;"><span lang="EN-GB" style="color: #222222; font-family: Titillium Web;">Pal Pacher. Cardiovascular Side Effects of New Antidepressants and Antipsychotics: New Drugs, old Concerns? Curr Pharm. 2004; 10(20): 2463–2475.</span></li><li class="MsoNormal" style="line-height: normal;"><span lang="EN-GB" style="color: #222222; font-family: Titillium Web;">Wang M.<span lang="EN-GB" style="color: black; line-height: 15.6933px;"> </span><span lang="EN-GB" style="color: black; line-height: 15.6933px;">Modified Xiaoyao San ameliorates depressive-like behaviors by triggering autophagosome formation to alleviate neuronal apoptosis.<u> Biomed Pharmacother</u></span><span face="Calibri, "sans-serif"" lang="EN-GB" style="color: black; line-height: 15.6933px;"><a href="https://www.blogger.com/blog/post/edit/9045216471569289288/4515415051011547411"><span>.</span></a></span><span lang="EN-GB" style="color: black; line-height: 15.6933px;"> 2019; Mar;111:1057-1065<i>. </i></span></span></li><li class="MsoNormal" style="line-height: normal;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;">John JB. The Efficacy of Acupuncture in the Treatment of
Major depression in Women. Psychological Science. 1998; 9(5): 397-401.</span><span lang="EN-GB"><o:p></o:p></span></span></li>
<li class="MsoNormal" style="line-height: normal;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;">Han
Cui. Clinical study on Electro-acupuncture
treatment for 30 cases of mental depression. Journal of Traditional
Chinese Medicine. 2004; 24 (3): 172-176.</span><span lang="EN-GB"><o:p></o:p></span></span></li>
<li class="MsoNormal" style="line-height: normal;"><span style="font-family: Titillium Web;"><span lang="EN-GB" style="color: #222222;">Joo
Im. Laser acupuncture for mild to moderate
depression in a primary care setting – a randomised controlled trial
Acupunct Med 2005; 23(3):103-111.</span><span lang="EN-GB"><o:p></o:p></span></span></li>
</ol><div><span style="color: #222222; font-family: Titillium Web;"><span>Note: * First version published in 24th December 2010, updated version at 21st February 2022. </span><br /><span> </span></span></div>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com1tag:blogger.com,1999:blog-9045216471569289288.post-40057203940910968382022-01-23T01:56:00.000+00:002022-01-23T01:56:01.478+00:00Post COVID "Brain Fog"<iframe width="480" height="270" src="https://youtube.com/embed/vPhdS-CA-lQ" frameborder="0"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-33766682489597782772021-08-05T16:48:00.001+01:002021-08-05T16:48:50.779+01:00How can we conquer the Covid pandemic ?<iframe style="background-image:url(https://i.ytimg.com/vi/It_i7U7OjfU/hqdefault.jpg)" width="480" height="270" src="https://youtube.com/embed/It_i7U7OjfU" frameborder="0"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-36125442291007162702021-07-08T10:57:00.011+01:002021-07-21T12:24:57.568+01:00How to prevent delta variant? <p> <span style="color: #2b00fe; font-family: georgia; font-size: x-small;">Tiejun Tang<br /></span></p><p class="MsoNormal"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"></span></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgWRWR3cL74iiyQle93bGo1oFM0DtGx0ZNOepjCgR29VvksS8PlArRv-MZ600TaOxx7gGQB7uQXBcYs3DfB242AiU_wy2s1_LMIl33mfdYTbQIr5CUVVHlRldH7VW2SXiKSTYmS5auFyx4/s2048/_118980625_indian_variant_england-2021-06-17-nc-002.png" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="1440" data-original-width="2048" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgWRWR3cL74iiyQle93bGo1oFM0DtGx0ZNOepjCgR29VvksS8PlArRv-MZ600TaOxx7gGQB7uQXBcYs3DfB242AiU_wy2s1_LMIl33mfdYTbQIr5CUVVHlRldH7VW2SXiKSTYmS5auFyx4/s320/_118980625_indian_variant_england-2021-06-17-nc-002.png" width="320" /></a></div><span style="font-family: georgia; font-size: medium;"><div style="text-align: justify;">The Covid pandemic has spread globally for one and a
half years, and many European countries have experienced three peaks. Why does
this pandemic seem to be endless? The main reason is the mutation of the virus.
First, the Alpha variant appeared in the UK, and then the Beta variant appeared
in South Africa, the Gamma variant appeared in Brazil, and then the Delta
variant appeared in India.</div><o:p></o:p></span><p></p><p class="MsoNormal" style="text-align: justify;"><span style="font-family: georgia; font-size: medium; line-height: 115%;">Genetic mutation is the natural to a virus. As you
know many people have been vaccinated for influenza in the past, but they still
have the flu. That is because the influenza virus is constantly mutating. So
does the Coronavirus. <o:p></o:p></span></p><p class="MsoNormal" style="text-align: justify;"><span style="font-family: georgia; font-size: medium; line-height: 115%;">Currently, there is no effective treatment drug for
the Covid virus. Doctors mainly rely on vaccines to control the pandemic, but
the speed of vaccine research and development cannot keep up with the speed of
virus mutation. Therefore, human beings are in a passive situation in the
battle against the virus.<o:p></o:p></span></p><p class="MsoNormal" style="text-align: justify;"><span style="font-family: georgia; font-size: medium;"><span style="line-height: 115%;">Virologist </span><a href="https://www.business-standard.com/article/current-affairs/coronavirus-mutations-may-reduce-efficacy-of-vaccines-shahid-jameel-121041400321_1.html"><span style="line-height: 115%;">Shahid
Jameel</span></a><span style="line-height: 115%;">, director of the Trivedi School of Biosciences at
Ashoka University, said "we don't yet know whether further mutations would
make current vaccines useless, this is unlikely. However, the efficacy of
vaccines may be reduced due to mutations."<o:p></o:p></span></span></p><p class="MsoNormal" style="text-align: justify;"><span style="font-family: georgia; font-size: medium; line-height: 115%;"><a href="https://www.nature.com/articles/d41586-021-01696-3">A Public Health
England study</a> published on 22 May found that a single dose of either
AstraZeneca's or Pfizer's vaccine reduced a person’s risk of developing
COVID-19 symptoms caused by the Delta variant by 33%, compared to 50% for the
Alpha variant. A second dose of the AstraZeneca vaccine boosted protection
against Delta to 60% (compared to 66% against Alpha), while two doses of
Pfizer’s jab were 88% effective (compared to 93% against Alpha).<o:p></o:p></span></p><p class="MsoNormal" style="text-align: justify;"><span style="font-family: georgia; font-size: medium; line-height: 115%;">The third wave of pandemic was caused by Delta
variant. How to prevent the Delta variant? We can’t just pin our hopes on
vaccines, we need some new ideas.<o:p></o:p></span></p><p class="MsoNormal" style="background: white; line-height: normal; margin-bottom: 0cm; text-align: justify;"><span style="font-family: georgia; font-size: medium;"><span style="color: #050505; mso-fareast-font-family: "Times New Roman";">My PhD tutor professor
</span><a href="https://en.wikipedia.org/wiki/Deng_Tietao"><span style="mso-fareast-font-family: "Times New Roman";">Deng Tietao</span></a><span style="color: #050505; mso-fareast-font-family: "Times New Roman";"> used to be the leader of the Chinese Medicine Expert Group on
SARS in the State Administration of Traditional Chinese Medicine in 2003. I
found his calligraphy last year while I studied his clinical experience on anti
SARS. I translated it in English. He said: "The prevention and treatment
of influenza is the advantage of traditional Chinese medicine. No matter how
virus changes, it couldn’t escape the palm of traditional Chinese medicine. The
curative effect of Chinese medicine on SARA and swine flu is the evidence.
Researching on Chinese medicine to prevent viral infectious diseases, to
replace immune injection, it will benefit the whole world." His exposition
ten years ago still gives us a lot of inspiration for today’s pandemic. </span><span style="color: #050505;"> </span></span></p><p class="MsoNormal" style="background: white; line-height: normal; margin-bottom: 0cm;"></p><div class="separator" style="clear: both; text-align: justify;"><span style="font-size: medium;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcaGl2u0FKrdJhvZe3MrJTbNpu2X3B8QUpGoYI2wCgk0F6r22AJolsSfULZWzXPnLtqt5NfnT39MHvn_5s5SvyOX_7z6Syz9_GN32eDRhy6aswxEbVu21C33Vq8sPflgKHjyl_7e8rLzQ/s588/20200326145503448248.jpg" style="margin-left: 1em; margin-right: 1em;"></a></span></div><span style="font-family: georgia; font-size: medium;"><div style="text-align: justify;"><span style="clear: right; float: right; font-family: georgia; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="401" data-original-width="588" height="218" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcaGl2u0FKrdJhvZe3MrJTbNpu2X3B8QUpGoYI2wCgk0F6r22AJolsSfULZWzXPnLtqt5NfnT39MHvn_5s5SvyOX_7z6Syz9_GN32eDRhy6aswxEbVu21C33Vq8sPflgKHjyl_7e8rLzQ/w320-h218/20200326145503448248.jpg" width="320" /></span><span style="background-color: white; color: #050505;">Different from the
mechanism of vaccines, Chinese herbal medicine anti the viral infectious
diseases by enhancing the body’s own immunity. Studies have shown that Chinese
herbal compound has a multi-target action. It not only acts on the cellular
immune system, but also on humoral immune system. Chinese herbal medicine
preparation likes a great sky net for viruses. That is why Professor Deng
Tietao can confidently say: "No matter how the virus changes, it cannot
escape the palm of Chinese medicine."</span></div></span><p class="MsoNormal" style="background: white; line-height: normal; margin-bottom: 0cm; text-align: justify;"><span style="font-family: georgia; font-size: medium;"><span style="color: #050505;">Based on Professor
Deng’s clinical experience, combined with the latest research results of modern
pharmacology, I developed </span><a href="https://chinesemedicinesalon.blogspot.com/2020/03/why-this-formula-can-be-used-to-prevent.html"><span style="mso-fareast-font-family: "Times New Roman";">Modified Yupingfeng San</span></a><span style="color: #050505;"> for the prevention of Covid 19.</span></span></p><p class="MsoNormal" style="background: white; line-height: normal; margin-bottom: 0cm; text-align: justify;"><span style="color: #050505; font-family: georgia; font-size: medium; mso-fareast-font-family: "Times New Roman";">It showed a satisfactory
prevention effect on the subject groups in UK, North America and Taiwan. <o:p></o:p></span></p><p class="MsoNormal" style="background: white; line-height: normal; margin-bottom: 0.0001pt; text-align: left;"></p><div style="text-align: justify;"><span style="background-color: transparent; font-family: georgia; font-size: medium;">Due to the mutation of the virus, the pandemic is
difficult to control. I suggest that in addition to vaccines, traditional alternative
medicine therapies should be selected as a complementary preventive method.</span></div><span style="background-color: transparent;"><div style="text-align: justify;"><br /></div></span><p></p><span style="color: #2b00fe; font-family: georgia;"></span><p></p>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com1tag:blogger.com,1999:blog-9045216471569289288.post-31155207157845760012021-06-01T15:49:00.005+01:002021-07-08T11:06:55.211+01:00Anti Covid 19 pandemic under the guidance of Professor Deng Tietao's aca...<span style="font-family: georgia; font-size: medium;"><span color="rgba(0, 0, 0, 0.9)" face="-apple-system, system-ui, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", "Fira Sans", Ubuntu, Oxygen, "Oxygen Sans", Cantarell, "Droid Sans", "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Lucida Grande", Helvetica, Arial, sans-serif" style="background-color: white;">The 3rd Traditional Medicine Forum was a international online conference hosted by WTMF and co-sponsored by the World Health Organization. I am honored to be invited to speak at this international conference as the only speaker from UK.</span><br style="background-color: white; box-sizing: inherit; color: rgba(0, 0, 0, 0.9); line-height: inherit;" /></span><div><span style="font-family: georgia; font-size: medium;"><span face=""Segoe UI Historic", "Segoe UI", Helvetica, Arial, sans-serif" style="background-color: white; color: #050505; white-space: pre-wrap;"><span color="rgba(0, 0, 0, 0.9)" face="-apple-system, system-ui, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", "Fira Sans", Ubuntu, Oxygen, "Oxygen Sans", Cantarell, "Droid Sans", "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Lucida Grande", Helvetica, Arial, sans-serif">Professor Deng Tietao has over 80 years clinical experience. In 2003 under his supervision China conquered SARS in about 3-4 month. Covid 19 also called SARS-CoV-2. I hope Prof. Deng’s clinical experience on anti SARS can help to anti the pandemic today.</span> </span> </span></div><div><br /></div><iframe frameborder="0" height="270" src="https://youtube.com/embed/7uSzlUs3nTM" width="480"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-83225054279984144272021-02-08T09:55:00.002+00:002021-02-08T09:56:10.117+00:00Where and when acupuncture came from ?<iframe width="480" height="270" src="https://youtube.com/embed/yGiGEu6KlkY" frameborder="0"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com2tag:blogger.com,1999:blog-9045216471569289288.post-68740571742378190712020-10-18T19:16:00.001+01:002020-10-18T19:16:44.855+01:00How to prevent the second wave of COVID 19?<iframe style="background-image:url(https://i.ytimg.com/vi/fRFonza6L9Y/hqdefault.jpg)" width="480" height="270" src="https://www.youtube.com/embed/fRFonza6L9Y" frameborder="0"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com3tag:blogger.com,1999:blog-9045216471569289288.post-50586323163346725502020-08-24T09:43:00.001+01:002020-08-24T09:43:15.500+01:00Is antidepressant better than painkiller for chronic pain ?<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/jTxOQIxZzh0" width="480"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-83046112017922108622020-08-19T03:51:00.040+01:002020-08-19T21:39:37.712+01:00The use of Traditional Chinese Medicines to treat COVID 19 may cause more good than harm<p style="text-align: left;"><span style="color: #2b00fe; font-family: georgia; font-size: small;"><span style="line-height: 150%; text-align: justify;">Tiejun Tang</span></span></p><div style="text-align: left;"><span style="color: #2b00fe; font-family: georgia; font-size: small;"><span style="line-height: 150%; text-align: justify;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj42v83llmfQwQtTRMTTDEk-_RshEJBinuxlJ8xxH11ONDOAxUrDkxqNFDYiURLhmRaSthPV1KYhA7nYiwz8weVHhJW3hKIuZVvuBjfyQSM9BTOQFWOCiOTsdHjobJhV30iYiWxH2xx_O4/s300/download.jpg" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="168" data-original-width="300" height="134" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj42v83llmfQwQtTRMTTDEk-_RshEJBinuxlJ8xxH11ONDOAxUrDkxqNFDYiURLhmRaSthPV1KYhA7nYiwz8weVHhJW3hKIuZVvuBjfyQSM9BTOQFWOCiOTsdHjobJhV30iYiWxH2xx_O4/w240-h134/download.jpg" width="240" /></a></div></span></span></div><div style="text-align: left;"><p style="background: white; line-height: 115%; margin: 0cm 0cm 0.0001pt; text-align: justify;"></p><p class="xmsonormal" style="background: white; line-height: 150%; margin: 12pt 0cm 0.0001pt; text-align: justify;"><span face="" style="font-family: georgia, serif;">This morning I read an article from the
website of Professor Edzard Ernst. The article title is “The use of Traditional
Chinese Medicines to treat SARS-CoV-2 may cause more harm than good”. I totally
disagree with this opinion and after some investigation, I would like to change
a few words in the title of his paper -- "The use of Traditional Chinese
Medicines to treat COVID 19 may <b><u>cause more good</u></b> than
harm."<o:p></o:p></span></p><p class="xmsonormal" style="background: white; line-height: 150%; margin: 12pt 0cm 0.0001pt; text-align: justify;"><span face="" style="font-family: georgia, serif;">Actually Mr Ernst is not the author of
this article. This paper was originally published by two Australian doctors two
month ago <sup>[1].</sup> Their conclusion was mainly based on an
article which was published by a group of Japanese doctors in 2017. It was a
Meta-Analysis paper. The author using PubMed and Ichushi-Web-the database of
the Japan Medical Abstracts Society to identify articles published between 1996
and 2015 describing patients with Japanese herbal medicine induced pneumonia.
They found that 73 patients have been diagnosed with pneumonia after taking
Japanese herbal medicine<sup>[2] </sup>. The mean age at pneumonia
diagnosis was 63.2 <span style="border: 1pt none; mso-border-alt: none windowtext 0cm; padding: 0cm;">±</span> 15.5 years. The herbal formulas
they used were sho-saiko-to (</span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">小柴胡汤</span><span face="" style="font-family: georgia, serif;">) </span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">(</span><span face="" style="font-family: georgia, serif;">26%</span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">)</span><span face="" style="font-family: georgia, serif;">,
sairei-to </span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">(柴苓汤)(</span><span face="" style="font-family: georgia, serif;">16%</span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">)</span><span face="" style="font-family: georgia, serif;">,
seishin-renshi-in </span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">(清心莲子饮)</span><span face="" style="font-family: georgia, serif;"> (8%</span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">)</span><span face="" style="font-family: georgia, serif;">and
bofu-tsusyo-san (</span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">防风通圣散</span><span face="" style="font-family: georgia, serif;">) </span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">(</span><span face="" style="font-family: georgia, serif;">8%</span><span lang="" style="border: 1pt none; font-family: SimSun; mso-ascii-font-family: Georgia; mso-border-alt: none windowtext 0cm; mso-hansi-font-family: Georgia; padding: 0cm;">)</span><span face="" style="font-family: georgia, serif;">.These
formulas all are traditional Chinese medicine formulas which were widely used
for hundreds or thousands of years in China, but not for early stage common
cold or flu complaints. Chinese medicine diagnosis for early stage common
cold or flu is Taiyang syndrome and the treatment principle should be expelling
wind cold or wind heat. The indication of sho-saiko-to is Shaoyang syndrome and
of course it is not suitable for Taiyang syndrome. The other 3 formulas are all
not suitable for this stage of Taiyang syndrome. If the treatment missed the
target of diagnosis, it will not work at all.<o:p></o:p></span></p><p class="xmsonormal" style="background: white; line-height: 150%; margin: 12pt 0cm 0.0001pt; text-align: justify;"><span face="" style="font-family: georgia, serif;">In addition to the diagnosis problem, I
noticed that the mean age at pneumonia diagnosis was over 60. Elderly people
are easier to develop into pneumonia when they catch cold, that is common
sense. The conclusion of Mr Enomoto’s article was against the basic principle
of statistics -- age group differentiation.<o:p></o:p></span></p><p class="xmsonormal" style="background: white; line-height: 150%; margin: 12pt 0cm 0.0001pt; text-align: justify;"><span face="" style="font-family: georgia, serif;">Mr.Gray the author of that article
believes that the Chinese herb Scutellariae Radix (Huangqin) is the cause of
ARDS. Many of the Chinese medicine formulas which are used in Covid 19
treatment contain Huangqin. That is why he gets his opinion of more harm than
good. His evidence for this also came from a Japanese report <sup>[3]</sup>. In
this report only 5 patients have got ARDS after receiving the herbal treatment.
He uses this very small sample report to against the report from Dr Ren<sup>[4]</sup>
which includes 701 cases of Covid 19 with a positive result. From Mr Gray’s
article I cannot find any evidence based on a large sample RCT research or
laboratory research.<o:p></o:p></span></p><p class="xmsonormal" style="background: white; line-height: 150%; margin: 12pt 0cm 0.0001pt; text-align: justify;"><span face="" style="font-family: georgia, serif;">Mr Edzard Ernst is a very famous retired
professor and critic of Chinese medicine. We all benefit greatly from
constructive logically based criticism but this becomes wasteful and
distracting if the criticism is not based on the principles of medical
statistics, and is selective in it’s use of research results to support a personal
agenda. I would like to be able to say that this paper made a useful addition
to the discussion on the efficacy of Traditional Chinese Medicines in the
modern world, but unfortunately I cannot.<o:p></o:p></span></p><p class="xmsonormal" style="background: white; line-height: 150%; margin: 12pt 0cm 0.0001pt; text-align: justify;"><span face="" style="font-family: georgia, serif;">Just a few days ago, we received some
positive news from the US National Centre for Biotechnology Information (NCBI)
who stated that “overall,” treatment with the Chinese herbal medicine Lianhua
Qingwen for 14 days resulted in a “significantly higher rate of, and a shorter
time to, symptom recovery.” Their conclusion is "Traditional Chinese
medicine can help COVID 19 patients recover faster” <sup>[5]<o:p></o:p></sup></span></p><p style="background: white; line-height: 115%; margin: 12pt 0cm 0cm; text-align: justify;">
</p><p class="xmsonormal" style="background: white; line-height: 150%; margin: 12pt 0cm 0.0001pt; text-align: justify;"><span face="" style="font-family: georgia, serif;">I hope that every reader can have a
second thought about this topic. Always follow the science.<o:p></o:p></span></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><b style="mso-bidi-font-weight: normal;"><span face="" style="color: #0070c0; font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Reference:</span></b></p>
<ol start="1" type="1">
<li class="MsoNormal" style="line-height: normal; mso-list: l0 level1 lfo1; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; tab-stops: list 36.0pt;"><span face="" style="font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Paul E. Gray.
The use of Traditional Chinese Medicines to treat SARS-CoV-2 may cause
more harm than good. Pharmacol Res. 2020 Jun; 156: 104776.<o:p></o:p></span></li>
<li class="MsoNormal" style="line-height: normal; mso-list: l0 level1 lfo1; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; tab-stops: list 36.0pt;"><span face="" style="font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Enomoto Y.
Japanese herbal medicine-induced pneumonitis: a review of 73
patients. Respir. Investig. 2017; 55:138–144.<o:p></o:p></span></li>
<li class="MsoNormal" style="line-height: normal; mso-list: l0 level1 lfo1; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; tab-stops: list 36.0pt;"><span face="" style="font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Osamu
Sakamoto. Clinical and CT characteristics of Chinese medicine</span><span face="" style="font-family: "cambria math", serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">‐</span><span face="" style="font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">induced acute
respiratory distress syndrome. Respirology 2003;
8(3):344-50. doi: 10.1046.<o:p></o:p></span></li>
<li class="MsoNormal" style="line-height: normal; mso-list: l0 level1 lfo1; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; tab-stops: list 36.0pt;"><span face="" style="font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Ren J.L.
Traditional Chinese medicine for COVID-19 treatment. Pharmacol.
Res. 2020:104743.<o:p></o:p></span></li>
<li class="MsoNormal" style="line-height: normal; mso-list: l0 level1 lfo1; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; tab-stops: list 36.0pt;"><a href="https://www.blogger.com/blog/post/edit/9045216471569289288/8304611201792210862"><span color="" face="" style="color: windowtext; font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">https://www.onenews.ph/us-health-agency-says-traditional-chinese-medicine-can-help-covid-19-patients-recover-faster</span></a><span face="" style="font-family: georgia, serif; font-size: 12pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";"><o:p></o:p></span></li>
</ol><br /><p></p></div>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com3tag:blogger.com,1999:blog-9045216471569289288.post-41759208328073312162020-07-30T12:47:00.001+01:002021-05-12T09:58:29.073+01:00Post-viral syndrome after COVID 19 and its TCM treatment<p class="MsoNormal"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"><span style="color: #2b00fe;">Tiejun Tang</span></span></p><p class="MsoNormal" style="text-align: justify;"><span style="clear: right; float: right; font-family: "Times New Roman", serif; font-size: 12pt; line-height: 115%; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="602" data-original-width="958" height="161" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjd7riK1ESvAEQ1c5H-6IUnH_F7TVYlr-e_ZBx2Q9ANjNWt6LukOs7l-dH85OB_RMmvpFFXB7eTqXLfRN1ktNNXg2flvQafrigTXJ5Jl08tuRmWK9-TK-NW0OcYg5nE-II2lyDfRBBRnIU/w256-h161/maxresdefault.jpg" style="text-align: left;" width="256" /></span></p><p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman", serif; font-size: 12pt; line-height: 115%;">The peak of the Covid 19 pandemic has passed in the
UK and most Europe countries. Ma</span><span style="font-family: "Times New Roman", serif; font-size: 12pt; line-height: 115%;">ny Covid 19 patients showed some sequel
symptoms after th</span><span style="font-family: "Times New Roman", serif; font-size: 12pt; line-height: 115%;">eir body temperature returned to normal: the</span><span style="font-family: "Times New Roman", serif; font-size: 12pt;"> cough
disappeared, virus turned negative and they were discharged from hospital. Some
people called these symptoms Covid 19 sequelae. The formal name of this
condition should be called “Post Viral Syndrome after COVID 19.” At this stage,
patients showed different symptoms to different degrees. Western medicine
usually gives a basic symptomatic treatment. The effects are usually not satisfactory.
Traditional Chinese medicine (TCM) already shows a particularly good effect in
the acute phase of Covid 19. Additionally, in the post virus era it can also play
an important role on the Post-Viral syndrome of Covid 19. My opinion about this
syndrome and personal clinical experienceis as follows.</span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">The incidences of post-viral syndrome are various.Not
every Covid-19 patient will develop squeal symptoms. Most young patients or basically
healthy individuals can fully recover after the virus disappear - no squeal
symptoms remain. As Huangdi Neijing said: "The healthy qi strong person
will not get the illness, only qi deficiency person will become sick." However,
for elderly and weak patients, the incidence of squeal symptoms is quite high
and in some cases the symptoms may be severe and even life-threatening. The
incidence of different squeal symptoms varies. Common squeal symptoms mainly
include:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">1. Fatigue:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Fatigue is the most common and mildest sequel
symptom of Covid-19. More than half of Covid-19 patients have varying degrees
of fatigue. TCM theory believes that the main causes of fatigue are qi and
blood deficiency. Covid 19 patients have experienced high fever for up to 2-3
weeks. They have taking a variety of western medicines, and a large number of
bitter and coldness herbs which might injury healthy qi. Huangdi Neijing said:
“Normal body temperature produce healthy qi, but high fever will consume healthy
qi”. The healthy qi of patient is exhausted by the “pathogenic heat” caused by coronavirus.
This is the reason for fatigue. Modern medicine calls it "Post-Viral
fatigue syndrome"<sup>[1]</sup><span style="color: #0070c0;">. </span>Some
patients may develop to a chronic fatigue syndrome (CFS).<sup><o:p></o:p></sup></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">2. Depression:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">After few months of lockdown, almost everyone has a
certain degree of negative psychological impact. For patients with Covid 19,
they have gone through several weeks of isolated treatment and some severe
cases have experienced it in ICU. They have experienced the life and death test.
The horrible memory about the ventilator and the witnessing the death of other
patients became a negative psychological stimulation to patients. After being
discharged from hospital some patients showed many psychological or physical
symptoms such as depression, panic attack, restlessness, insomnia and worry
about virus recurrence. These symptoms are called "Post-traumatic Stress
Disorder" (PTSD) in western medicine. Although some people who are not
infected by Covid 19 also experienced depression due to the scare about the pandemic
and the changes in their life and work, this kind of post-viral depression is common.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>3. Pulmonary
Fibrosis:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">According to the report 21.5% of SARA patients had showed
the imaging of pulmonary fibrosis during the recovery period. <sup>[2]</sup>
The main symptoms were dry cough and progressive dyspnea. Imaging of the lungs
showed characteristic changes in pulmonary fibrosis. The proportion of
pulmonary fibrosis in Covid 19 should be very familiar with SARA.<sup>[3]</sup>
It has been reported that the average survival time after diagnosis of
pulmonary fibrosis is only 2.-3 years, and the mortality rate is higher than
most of cancer. Pulmonary fibrosis is called "chronic cancer."
Western medicine treats pulmonary fibrosis using two newly developed drugs,
pirfenidone and nintedanib, but both have strong gastrointestinal side effects.
Research on the treatment of pulmonary fibrosis with Chinese herbal medicine
has showed satisfactory results.<sup>[4]<o:p></o:p></sup></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">4. Fibromyalgia:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Some patients experienced body ache after Covid 19,
and the pain is wandering. The position is mainly in the muscles and bones of
the limbs and back. The pain is usually combined with fatigue and depression.
Western medicine diagnoses it as "fibromyalgia" (FM). The etiology of
this disease is not clear, but it is believed to be related to traumatic
stress, immune disorders, Epstein-Barr virus infection and other factors. The cytokine
storm caused by Covid 19 virus is very likely to be a new cause of
fibromyalgia.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">5. Heart failure:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Heart and lungs all located in the chest (upper Jiao).
According to the Zang-fu theory of TCM, heart is the "officer of the
monarch", it dominates blood circulation; Lung is the "officer of
prime minister", it dominates the qi. The heart and lungs are extremely
closely related in their physiological functions, and they also influence each
other in pathology. When lungs get ill heart must be affected. Western medical
research shows that Covid 19 first invaded the human body through the
angiotensin-converting enzyme 2 (ACE2) receptor located on the cell surface.
Many patients develop viral myocarditis and pericarditis after Covid 19, which
leads to heart failure. For some elderly people who have history of coronary
heart disease, after the Covid 19, the patients can still be aggravated by
heart failure or arrhythmia. This became the main reason of death for elderly
Covid 19 patients.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">6. Lost the sensation of smell and taste:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">The Huangdi Neijing states that “The lung qi flows
through the nose, the smell function depend on the normal function of lungs.” In
Covid 19 patients, their lung qi was injured by the virus. Patients lost smell sensation.
In some cases patient also loss of taste. This condition is very common, and it
has even become one of the characteristic symptoms for the diagnosis of covid
19. After the virus, the recovery of smell and taste is often an extremely slow
process, and it is still uncertain whether it can be completely recovered.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">7. Impaired reproductive function:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Studies have shown that Covid19 destroys lung cells
and/or ACE2 protective pathways. The expression of .ACE2 in the ovaries and
testis indicates that this enzyme affects germ cells and fertility function.
Therefore, theoretically, Covid 19 may cause male or female infertility. The
impact of the virus on the fertility function will be gradually revealedin the
future.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">The above seven points are the main manifestations
of the post-viral syndrome of Covid 19. In addition, there are other diseases such
as acute and chronic kidney damage, proteinuria, and stroke which are induced
by Covid 19.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><b style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Chinese
medicine treatment:<span style="mso-spacerun: yes;"> </span></span></b><span style="color: #0070c0; font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">TCM has shown an excellent effect in the treatment
and prevention of Covid 19. The three formulas and three remedies recommended
by China's<span style="background: rgb(248, 249, 250);"> National Health Commission </span>are
widely used in China during the pandemic. For treatment of chronic diseases TCM
may show more advantages. I treated some patients with post-viral syndrome in
the past few months. I would like to share my personal experience on the
treatment of this syndrome. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>1) Post-viral
fatigue syndrome: The main pathogenesis of this syndrome is deficiency of qi
and blood. TCM theory believes “<span style="background: white;">If there is
deficiency, supplement it”. </span>TCM usually use Sijunzi decoction for replenishing
qi and Siwu decoction for nourishing blood. For the patient with more digestive
system disorders, we should benefit lung by tonifying spleen. Guipi Wan, or
ChenXia Liujunzi Decoction can be selected. Spleen and stomach are the source
of qi and blood. If spleen is strong, the qi and blood are sufficient, and the fatigue
will be improved. The food therapy can be applied. Add some Huangqi, Dangshen,
Danggui, Longyan, Gouqizi while cooking soups. </span><a href="http://chinesemedicinesalon.blogspot.com/2010/03/wuzhualong-efficient-herb-of-south.html"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Wuzhualong</span></a><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">
is the most favourite herb of my tutor, </span><a href="https://en.wikipedia.org/wiki/Deng_Tietao"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Professor Deng Tietao</span></a><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">.
It can not only invigorate qi, but also has the effect of reducing phlegm and
relieving cough. It is a very good choice for the Post-viral fatigue after
Covid 19.<span style="color: #0070c0;"><o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">2) Post-viral depression and PTSD: The depression
after Covid 19 is mostly due to liver-qi stagnation, and Xiaoyaosan and Chaihu Shugan
San can be used to relieve liver depression; PTSD symptoms are mostly due to
heart shen disturbed. Chinese medicine Baizi Yangxin Wan, Tianwang Buxin Wan
and Ganmai Dazao decoction can be selected.<span style="mso-spacerun: yes;">
</span>I recommend adding Baihe, Meiguihua, Suxinhua, Yujin etc. to release the
depression. Appropriate psychological treatment can help, but it is not
recommended to use antidepressantsif not very necessary. </span><a href="https://chinesemedicinesalon.blogspot.com/2010/12/merry-christmas-and-depression-go-away.html"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Chinese
herbal medicine is a natural way of anti-depression.</span></a><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">3) Post-viral pulmonary fibrosis: For the
treatment of pulmonary fibrosis, Chinese medicine adopts the treatment
principles of clearing dryness and moisturizing the lungs, lowering qi and relieving
asthma, promoting blood circulation and removing blood stasis. The
prescriptions are mostly Qingzao Jiufei Decoction, Suzi Jiangqi Decoction,
Sanzi Yangqin Decoction, plus Danshen, Chishaoyao, Sanqi and other herbs for
promoting blood circulation and removing blood stasis. There are many research
reports showing that single or compound Chinese medicine can significantly
improve pulmonary fibrosis in rats caused by bleomycin<sup>[5]</sup>. Among
them, the classic ancient prescription </span><a href="https://chinesemedicinesalon.blogspot.com/2020/03/why-this-formula-can-be-used-to-prevent.html"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Yupingfeng
San</span></a> <span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">has
shown good effect in anti-pulmonary fibrosis. I also have an English article
devoted to discussing the mechanism of Yupingfeng on the prevention and
treatment of Covid 19.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"><span style="mso-spacerun: yes;"> </span>4)
Fibromyalgia caused by the virus: Acupuncture has a very good effect on the
treatment of </span><a href="https://chinesemedicinesalon.blogspot.com/2015/08/"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">fibromyalgia.</span></a><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">
Acupuncture should be the first choice for muscle and joint pain after Covid 19.There
are many research reports on the mechanism of acupuncture analgesia. Not only
relieving pain, acupuncture is also a comprehensive treatment measure, which
can also alleviate related symptoms such as, depression, and sleep disorders.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">5) Heart failure: Heart failure is more common in
severe case of Covid 19. In some mild cases tachycardia and arrhythmia can be
found after the virus. TCM usually chooses Xuefu Zhuyu Decoction and Shengmai San
to treat the heart failure. Studies have confirmed that these prescriptions can
improve myocardial blood supply, reduce myocardial oxygen consumption, improve
microcirculation and many other effects, thereby gradually improving heart
failure.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">6) Loss of smell and taste after the Covid 19:
Acupuncture at Yingxiang (LI 20) and Bitong points beside the nose, and certain
specific areas of the scalp acupuncture, to help restore the sense of smell; Acupuncture
on the face, cheeks, and neck acupoints such as Dichang (ST4), Jiache (ST6) and
Lianquan (RN23) and combined with strengthening spleen herbs, can help restore
the sense of taste.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">7) Infertility after Covid 19: </span><a href="https://chinesemedicinesalon.blogspot.com/2019/11/magical-five-kinds-of-seeds.html"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Wuzi
Yanzong Wan</span></a><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;"> can improve sperm quantity and quality,
improve sperm motility, improve semen liquefaction time, and increase
reproductive ability. It is used for the treatment of male infertility<sup>[6]</sup>.
For female infertility Nuangong Yunzi Wan, Zishen Yutai Wan, or Fuke Bazhen Wan
can be selected according to the syndrome differentiation. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">After the peak of the pandemic passed, it can be
predicted that the peak of post-viral syndrome will follow. Ray<sup>[1] </sup>suggests
that prevalence of fatigue-related symptoms after Covid 19 infection should be
studied first, and pragmatic, relatively low-cost techniques should be explored
to treat post-viral fatigue. Relieve symptoms and improve the quality of life
of people affected by the long-term sequelae of Covid 19. I think Chinese
medicine should be the best option. Patients and doctors must be aware of the
post-viral syndrome, and apply suitable treatment,ensuring a complete recovery and
to prevent it from recurring.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span style="font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">If the patient's virus test has turned negative, it
is better co</span></p><div class="separator" style="clear: both; text-align: center;"><br /></div>mbine acupuncture and herbs treatment together because the effects
can enhance each other. If the virus still positive, patient can get the herbal
medicine treatment or diet advice through the online consultation. It is my wishing
patients emerge from the shadow of Covid 19 as soon as possible and return to their
normal and healthy life.<o:p></o:p><p></p>
<p class="MsoNormal"><span style="color: #0070c0; font-family: "Times New Roman","serif"; font-size: 12pt; line-height: 115%;">Reference:<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpFirst" style="background: white; line-height: 16.2pt; margin-bottom: 6.0pt; margin-left: 36.0pt; margin-right: 0cm; margin-top: 12.0pt; margin: 12pt 0cm 6pt 36pt; mso-add-space: auto; mso-list: l0 level1 lfo1; mso-outline-level: 1; text-indent: -18pt;"><!--[if !supportLists]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><span style="mso-list: Ignore;">1.<span style="font: 7pt "Times New Roman";">
</span></span></span><!--[endif]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;">Ray Perrin. Into the looking glass: Post-viral
syndrome post COVID-19. </span><span style="background: white; font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt;">Med Hypotheses. 2020
Nov; 144: Published online 2020 Jun 27.</span><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="background: white; line-height: 16.2pt; margin-bottom: 6.0pt; margin-left: 36.0pt; margin-right: 0cm; margin-top: 12.0pt; margin: 12pt 0cm 6pt 36pt; mso-add-space: auto; mso-list: l0 level1 lfo1; mso-outline-level: 1; text-indent: -18pt;"><!--[if !supportLists]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><span style="mso-list: Ignore;">2.<span style="font: 7pt "Times New Roman";">
</span></span></span><!--[endif]--><span style="background: white; font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt;">Xie L Dynamic changes
of serum SARS-coronavirus IgG, pulmonary function and radiography in patients
recovering from SARS after hospital discharge[J]. Respir Res, 2005,6:5. DOI:
10.1186/1465-9921-6-5.</span><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="background: white; line-height: 16.2pt; margin-bottom: 6.0pt; margin-left: 36.0pt; margin-right: 0cm; margin-top: 12.0pt; margin: 12pt 0cm 6pt 36pt; mso-add-space: auto; mso-list: l0 level1 lfo1; mso-outline-level: 1; text-indent: -18pt;"><!--[if !supportLists]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><span style="mso-list: Ignore;">3.<span style="font: 7pt "Times New Roman";">
</span></span></span><!--[endif]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-font-kerning: 18.0pt;">Peter M. </span><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt;">Pulmonary
fibrosis and COVID-19: the potential role for antifibrotic therapy. The Lancet
Respiratory Medicine. May 15, 2020 </span><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="background: white; line-height: 16.2pt; margin-bottom: 6.0pt; margin-left: 36.0pt; margin-right: 0cm; margin-top: 12.0pt; margin: 12pt 0cm 6pt 36pt; mso-add-space: auto; mso-list: l0 level1 lfo1; mso-outline-level: 1; text-indent: -18pt;"><!--[if !supportLists]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><span style="mso-list: Ignore;">4.<span style="font: 7pt "Times New Roman";">
</span></span></span><!--[endif]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt;">Yunping Bai. A Chinese Herbal Formula
Ameliorates Pulmonary Fibrosis by Inhibiting Oxidative Stress via Upregulating
Nrf2. </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005894/"><span style="background: white; font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt;">Front Pharmacol</span></a><span style="background: white; font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt;">. 2018; 9: 628.</span><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpMiddle" style="background: white; line-height: 16.2pt; margin-bottom: 6.0pt; margin-left: 36.0pt; margin-right: 0cm; margin-top: 12.0pt; margin: 12pt 0cm 6pt 36pt; mso-add-space: auto; mso-list: l0 level1 lfo1; mso-outline-level: 1; text-indent: -18pt;"><!--[if !supportLists]--><span style="font-family: "Times New Roman","serif"; font-size: 10pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><span style="mso-list: Ignore;">5.<span style="font: 7pt "Times New Roman";">
</span></span></span><!--[endif]--><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-bidi-font-weight: bold; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;">Jiepeng Wang. Danggui Buxue
Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through
inhibiting transforming growth factor-β1/Smad3/ plasminogen activator
inhibitor-1 signaling pathway. </span><span style="font-family: "Times New Roman","serif"; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman";">J
Tradit Chin Med. 2020 Apr;40(2):236-244.</span><span style="font-family: "Times New Roman","serif"; font-size: 10pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="background: white; line-height: 16.2pt; margin-bottom: 6.0pt; margin-left: 36.0pt; margin-right: 0cm; margin-top: 12.0pt; margin: 12pt 0cm 6pt 36pt; mso-add-space: auto; mso-list: l0 level1 lfo1; mso-outline-level: 1; text-indent: -18pt;"><!--[if !supportLists]--><span style="font-family: "Times New Roman","serif"; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><span style="mso-list: Ignore;">6.<span style="font: 7pt "Times New Roman";"> </span></span></span><!--[endif]--><span class="authors-list-item"><span style="font-family: "Times New Roman","serif";">Dixin
Zou. </span></span><span style="font-family: "Times New Roman","serif";">Analysis
of pharmacological mechanisms and targets mining of Wuzi-Yanzong-Wan for
treating non-obstructive oligoasthenospermia<span class="period">.<span style="mso-spacerun: yes;"> </span> </span>Biomed Pharmacother. <span class="cit">2019 Jul; 115:108898.</span></span><span style="font-family: "Times New Roman","serif"; mso-fareast-font-family: "Times New Roman"; mso-font-kerning: 18.0pt;"><o:p></o:p></span></p><br />Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-78756960104028539042020-07-18T23:11:00.001+01:002020-07-18T23:11:59.298+01:00How to treat Post Viral Syndrome after COVID 19 ?<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/MyNFXqJavQM" width="480"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-87632787239339706142020-07-12T22:02:00.001+01:002020-07-12T22:02:26.644+01:00How Yupingfeng effect on Covid 19 ?<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/2_v851j9FTc" width="480"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0tag:blogger.com,1999:blog-9045216471569289288.post-55718464078792239302020-05-30T21:25:00.001+01:002020-05-30T21:25:50.812+01:00How Acupuncture Works ?<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/ER-P4MvmuLM" width="480"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com1tag:blogger.com,1999:blog-9045216471569289288.post-8726265387173675652020-05-29T10:30:00.001+01:002020-05-29T10:30:25.022+01:00A Hypertension Tea<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/GOxe9Dxlcyk" width="480"></iframe>Tiejun Tanghttp://www.blogger.com/profile/12551006740213532432noreply@blogger.com0