The 5 ingredients of WZYZW are 5 kinds of seeds. They are Tusizi, Gouqizi, Fupenzi, Wuweizi, Cheqianzi. In recent few decades it has been found that this pill not only used to treat male infertility bur also can be used to treat female reproductive system diseases. It can regulate many hormone levels which related to fertility function. It can increase the success rate of IVF treatment and regulate women's menopausal symptoms.
Why these five kinds of seeds have so magical effect on fertility treatment? Some researchers did a lot of scientific researches to find out the mysteries behind.
Zou
D use Ultra-Performance LC coupled with ESI-linear ion trap-Orbitrap tandem
mass spectrometry technique analysed chemical constituents of WZYZW.
106 compounds were found in these 5 seeds, including
organic acids, flavonoids, phenylpropanoids, alkaloids and terpenoids. [1]
Ji HJ reported oral
administration of WZYZW for 3 weeks, it can significantly increased testes
weight, sperm quantity and motility, and reduce testicular damage. Meanwhile,
WZYZW treatment significantly reversed the reduction of serum testosterone, and
decreased testes malondialdehyde and oxidative stress index relative to the
radiated mice. It also effectively
prevented the down regulation of proliferating cell nuclear antigen (PCNA)
expression in testes induced by x-ray irradiation.[2]
Xu YP use WZYZW on the spermatogenesis
and specific secretory functions of sertoli cells in rat model and to
investigate the underlying mechanism. Serum levels of follicle-stimulating hormone
inhibit B and testosterone was evaluated using enzyme-linked immunosorbent
assay. Androgen-binding protein gene expression and transferrin protein
expression in testis tissue specimens of all rats were determined using RT-PCR and
Western blotting analysis, respectively. Histopathological alterations in the
testis were determined using Johnsen's score. The research found WZYZW
can increase the specific secretory functions of sertoli cells. Furthermore,
serum testosterone level and Johnsen's score of the testis increased greatly
compared with the model group. [3]
Yang
Z applied molecular biology technique to detect WZYZW. The results showed this
pill can restore testicular
structure and significantly increased the histology score in the
oligoasthenozoo spermic rats. In addition, it also significantly increased the
serum levels of gonadotropin release hormone, luteinizing hormone, estradiol,
and testosterone and decreased that of follicle-stimulating hormone. [4]
A latest research use WZYZW to treat non-obstructive oligoasthenozoospermia (NOA). In this study, both plasma and urine metabolomics profiling was first analysed to explore the therapeutic mechanisms of WZYZW on NOA rats induced by removal of the unilateral testicle. Then, 106 identified compounds comprising WZYZW, for which putative targets were discovered using systems pharmacology, were systematically analysed via mRNA microarrays to validate their putative targets. The results suggested that WZYZW plays key roles in modulating the concentrations of 18 metabolites in the metabolism of amino acids, lipids and so on, normalizing the metabolic phenotype and regulating metabolic disorders. Moreover, 27 targets of WZYZW (23 compounds) against NOA were validated, and metabolomics-tested metabolites were also found to be significantly related to these identified targets. [5]
Above research reports provide a strong scientific evidence of WZYZW. This magic pill should be a good choice for the infertility treatment of male and female.
A latest research use WZYZW to treat non-obstructive oligoasthenozoospermia (NOA). In this study, both plasma and urine metabolomics profiling was first analysed to explore the therapeutic mechanisms of WZYZW on NOA rats induced by removal of the unilateral testicle. Then, 106 identified compounds comprising WZYZW, for which putative targets were discovered using systems pharmacology, were systematically analysed via mRNA microarrays to validate their putative targets. The results suggested that WZYZW plays key roles in modulating the concentrations of 18 metabolites in the metabolism of amino acids, lipids and so on, normalizing the metabolic phenotype and regulating metabolic disorders. Moreover, 27 targets of WZYZW (23 compounds) against NOA were validated, and metabolomics-tested metabolites were also found to be significantly related to these identified targets. [5]
Above research reports provide a strong scientific evidence of WZYZW. This magic pill should be a good choice for the infertility treatment of male and female.
Reference:
- Zou D. Analysis of Chemical Constituents in Wuzi-Yanzong-Wan by UPLC-ESI-LTQ-Orbitrap-MS. Molecules. 2015; 20 (12):21373-404.
- Ji HJ. Wuzi Yanzong pill, a Chinese polyherbal formula, alleviates testicular damage in mice induced by ionizing radiation. BMC Complement Altern Med. 2016; 16(1):509.
- Xu YP. A Chinese herbal formula, Wuzi Yanzong pill, improves spermatogenesis by modulating the secretory function of Sertoli cells. Chin J Integr Med. 2014; 20(3):194-9.
- Yang Z. Effect of Wuzi Yanzong on Reproductive Hormones and TGF-β1/Smads Signal Pathway in Rats with Oligoasthenozoospermia. Evid Based Complement Alternat Med. 2019 Apr 16;2019:7628125.
- Zou D. Analysis of pharmacological mechanisms and targets mining of Wuzi-Yanzong-Wan for treating non-obstructive oligoasthenospermia. Biomed Pharmacother. 2019 Jul;115:108898. doi: 10.1016/j.biopha.2019.108898.
